@misc{10481/95479,
year = {2024},
month = {4},
url = {https://hdl.handle.net/10481/95479},
abstract = {A new family of six complexes based on 5-nitropicolinic acid (5-npic) and transition metals has been
obtained: [M(5-npic)2]n (MII = Mn (1) and Cd (2)), [Cu(5-npic)2]n (3), and [M(5-npic)2(H2O)2] (MII = Co (4),
Ni (5), and Zn (6)), which display 1D, 2D, and mononuclear structures, respectively, thanks to different
coordination modes of 5-npic. After their physicochemical characterization by single-crystal X-ray diffraction
(SCXRD), elemental analyses (EA), and spectroscopic techniques, quantum chemical calculations
using Time-Dependent Density Functional Theory (TD-DFT) were performed to further study the luminescence
properties of compounds 2 and 6. The potential anticancer activity of all complexes was tested
against three tumor cell lines, B16-F10, HT29, and HepG2, which are models widely used for studying
melanoma, colon cancer, and liver cancer, respectively. The best results were found for compounds 2
and 4 against B16-F10 (IC50 = 26.94 and 45.10 μg mL−1, respectively). In addition, anti-inflammatory
studies using RAW 264.7 cells exhibited promising activity for 2, 3, and 6 (IC50 NO = 5.38, 24.10, and
17.63 μg mL−1, respectively). This multidisciplinary study points to complex 2, based on CdII, as a promising
anticancer and anti-inflammatory material.},
organization = {Junta de Andalucía (FQM-394,
P21_00386, BIO-157, PAIDI-FQM-337, ProyExcel_00386, and
BFQM-650-ugr20)},
organization = {TED2021-132440B-I00 funded by MCIN/
AEI/10.13039/501100011033},
organization = {Universidad de Jaén, FEDER_UJA_2020 (project 2021/00627/
001)},
organization = {Ministerio de Ciencia e
Innovación for Ramón y Cajal contracts (the publication is
part of the grants RYC2021-034288-I and RYC2021-032522-I,
funded by MCIN/AEI/10.13039/501100011033 and by the
European Union “Next Generation-EU”/“PRTR”)},
organization = {Ministerio de Universidades and Next-Generation
funds for a Margarita Salas contract},
organization = {Universidad de Granada / CBUA},
publisher = {Royal Society of Chemistry},
title = {Modulating anti-inflammatory and anticancer properties by designing a family of metalcomplexes based on 5-nitropicolinic acid},
doi = {10.1039/D4DT00265B},
author = {García García, Amalia and Medina O'Donnell, Marta and Rojas Macías, Sara and Cano-Morenilla, Mariola and Morales, Juan and Quesada Moreno, María del Mar and Sáinz Pérez, Juan and Vitorica-Yrezabal, Iñigo J. and Rodríguez Diéguez, Antonio and Navarro, Amparo and Reyes Zurita, Fernando Jesús},
}