@misc{10481/95393,
year = {2024},
month = {9},
url = {https://hdl.handle.net/10481/95393},
abstract = {The challenge of transforming organized DNA structures into their metallized
counterparts persists in the scientific field. In this context, utilizing DNA
moleculesmodified with 7-deazapurine, provides a transformative solution. In
this study, we present the solution structure of a DNA duplex that can be
transformed into its metallized equivalent while retaining the natural base
pairing arrangement through the creation of silver-modified Watson-Crick
base pairs. Unlike previously documented X-ray structures, our research
demonstrates the feasibility of preserving the intrinsic DNA self-assembly
while incorporating AgI into the double helix, illustrating that the binding of
silver does not disrupt the canonical base-pairing organization. Moreover, in
our case, the uninterrupted AgI chain deviates from forming conventional
straight linear chains; instead, it adheres to a helical arrangement dictated by
the underlying DNA structure. This research challenges conventional
assumptions and opens the door to precisely design structures based on the
organization of highly stable Ag-DNA assemblies.},
organization = {Spanish MINECO (project PID2020-120186RBI00)},
organization = {Spanish MICIU (Salvador Madariaga Program, Ref. PRX19/00290)},
organization = {Junta de Andalucia (project P20_00702)},
organization = {Slovenian Research Agency (grants P1-0242 and J1-1704)},
organization = {Spanish Ministerio
de Ciencia e Innovación (PID2022-138479NB-I00)},
organization = {“Grup de Recerca de la Generalitat de Catalunya” (Ref. 2021 SGR
00668)},
organization = {CERIC-ERIC Consortium Project
20172040 and 20222132},
organization = {National
Science Foundation, under grant number NSF/CHE-1834750},
organization = {DOE Office of Science by Argonne
National Laboratory (ANL) under Contract No. DE-AC02-06CH11357},
publisher = {Nature Research},
title = {Unveiling the solution structure of a DNA duplex with continuous silver-modified Watson-Crick base pairs},
doi = {10.1038/s41467-024-51876-8},
author = {Javornik, Uroš and Pérez Romero, Antonio and López-Chamorro, Carmen and Smith, Rachelle M. and Dobado Jiménez, José Antonio and Palacios, Óscar and Bera, Mrinal K. and Nyman, May and Plavec, Janez and Galindo, Miguel A.},
}