@misc{10481/95282,
year = {2015},
url = {https://hdl.handle.net/10481/95282},
abstract = {Background
Individuals with cocaine and gambling addictions exhibit cognitive flexibility deficits that may underlie persistence of harmful behaviours.
Aims
We investigated the neural substrates of cognitive inflexibility in cocaine users v. pathological gamblers, aiming to disambiguate common mechanisms v. cocaine effects.
Method
Eighteen cocaine users, 18 pathological gamblers and 18 controls performed a probabilistic reversal learning task during functional magnetic resonance imaging, and were genotyped for the DRD2/ANKK Taq1A polymorphism.
Results
Cocaine users and pathological gamblers exhibited reduced ventrolateral prefrontal cortex (PFC) signal during reversal shifting. Cocaine users further showed increased dorsomedial PFC (dmPFC) activation relative to pathological gamblers during perseveration, and decreased dorsolateral
PFC activation relative to pathological gamblers and controls during shifting. Preliminary genetic findings indicated that cocaine users carrying the DRD2/ANKK Taq1A1+ genotype may derive unique stimulatory effects on shifting-related ventrolateral PFC signal.
Conclusions
Reduced ventrolateral PFC activation during shifting may constitute a common neural marker across gambling and cocaine addictions. Additional cocaine-related effects relate to a wider pattern of task-related dysregulation, reflected in signal abnormalities in dorsolateral and dmPFC.},
title = {Neural substrates of cognitive flexibility in cocaine and gambling addictions},
doi = {10.1192/bjp.bp.114.152223},
author = {Verdejo García, Antonio Javier and Clark, Luke and Verdejo Román, Juan and Albein Urios, Natalia and Martínez González, José Miguel and Gutiérrez Martínez, Blanca and Soriano-Mas, Carles},
}