@misc{10481/95165,
year = {2024},
month = {9},
url = {https://hdl.handle.net/10481/95165},
abstract = {Migraine (MI) is the most common neurological disease, affecting with 20% of the
world population. A subset of 25% of MI patients showcase concurrent vestibular
symptoms, which may classify as vestibular migraine (VM). Meniere’s disease
(MD) is a complex inner ear disorder defined by episodes of vertigo associated
with tinnitus and sensorineural hearing loss with a significant autoimmune/
autoinflammatory contribution, which symptoms overlap with VM. Blood samples
from 18 patients with MI (5), VM (5) and MD (8) and 6 controls were collected
and compared in a case–control study. Droplet-isolated nuclei from
mononuclear cells used to generate scRNAseq and scATACseq data sets from MI, VM and MD. MI and VM have no differences in their immune transcriptome;
therefore, they were considered as a single cluster for further analyses. Natural
Killer (NK) cells transcriptomic data support a polarisation triggered by Type
1 innate immune cells via the release of interleukin (IL)-12, IL-15 and IL-18.
According to the monocyte scRNAseq data, there were two MD clusters, one inactive
and one driven by monocytes. The unique pathways of the MI + VM cluster
were cellular responses to metal ions, whereas MD monocyte-driven cluster pathways
showed responses to biotic stimuli. MI and MD have different immune
responses. These findings support that MI and VM have a Type 1 immune lymphoid
cell response, and that there are two clusters of MD patients, one inactive
and one Monocyte-driven.},
organization = {K7013-B3414G Grant
from University of Sydney},
organization = {PI20-1126 grant from ISCIII
by FEDER Funds from the EU},
organization = {CLINMON-2 from
the Meniere’s Society UK},
organization = {Postdoctoral Fellowship (CD20/0153)},
publisher = {Wiley Online Library},
keywords = {Autoinflammation},
keywords = {Cytokines},
keywords = {Meniere disease},
title = {Multiomic-based immune response profiling in migraine, vestibular migraine and Meniere’s disease},
doi = {10.1111/imm.13863},
author = {Cruz-Granados, Pablo and Frejo, Lidia and Pérez Carpena, Patricia and Amor Dorado, Juan Carlos and Dominguez Durán, Emilio and Fernandez Nava, Maria Jose and Batuecas Caletrio, Angel and Haro Hernández, Elisheba and Martínez Martínez, Marta and López Escámez, José Antonio},
}