@misc{10481/95158,
year = {2024},
month = {8},
url = {https://hdl.handle.net/10481/95158},
abstract = {Introduction: Vaccine-induced immunity against COVID-19 generates antibody
and lymphocyte responses. However, variability in antibody titers has been
observed after vaccination, and the determinants of a better response should
be studied. The main objective of this investigation was to analyze the
inflammatory biomarker response induced in healthcare workers vaccinated
with BNT162b2, and its association with anti-Spike (a SARS-CoV-2 antigen)
antibodies measured throughout a 1-year follow-up.
Methods: Anti-spike antibodies and 92 biomarkers were analyzed in serum,
along with socio-demographic and clinical variables collected by interview
or exploration.
Results: In our study, four biomarkers (ADA, IL-17C, CCL25 and CD8a) increased
their expression after the first vaccine dose; and 8 others (uPA, IL-18R1, ENRAGE,
CASP-8, MCP-2, TNFb, CD5 and CXCL10) decreased their expression.
Age, body mass index (BMI), smoking, alcohol consumption, and prevalent
diseases were associated with some of these biomarkers. Furthermore, higher
baseline levels of T-cell surface glycoprotein CD6 and hepatocyte growth factor
(HGF) were associated with lower mean antibody titers at follow-up, while levels
of monocyte chemotactic protein 2 (MCP-2) had a positive association with
antibody levels. Age and BMI were positively related to baseline levels of MCP-2
(b=0.02, 95%CI 0.00-0.04, p=0.036) and HGF (b=0.03, 95%CI 0.00-0.06,
p=0.039), respectively. Conclusion: Our findings indicate that primary BNT162b2 vaccination had a
positive effect on the levels of several biomarkers related to T cell function, and a
negative one on some others related to cancer or inflammatory processes. In
addition, a higher level of MCP-2 and lower levels of HGF and CD6 were found to
be associated with higher anti-Spike antibody titer following vaccination.},
organization = {Consejería de Salud, Junta de Andalucía (Spain) under Grant PI-0198-2021},
publisher = {Frontiers Media},
keywords = {COVID-19},
keywords = {BTN162b2},
keywords = {SARS-CoV-2},
keywords = {Anti-spike antibodies},
title = {Evaluation of inflammatory biomarkers and their association with anti-SARS-CoV-2 antibody titers in healthcare workers vaccinated with BNT162B2},
doi = {10.3389/fimmu.2024.1447317},
author = {Leno Durán, Ester and Serrano-Conde Sánchez, Esther and Salas-Rodriguez, Ana and Salcedo-Bellido, Inmaculada and Barrios Rodríguez, Rocío and Fuentes, Ana and Viñuela, Laura and García, Federico and Requena Méndez, María del Pilar},
}