@misc{10481/94969,
year = {2021},
url = {https://hdl.handle.net/10481/94969},
abstract = {Cancer, like other chronic pathologies, is associated with the presence of hypoxic regions due to the
uncontrolled cell growth. Under this pathological hypoxic condition, various molecular signalling pathways are
activated to ensure cell survival, such as those that govern angiogenesis, erythropoiesis, among others. These
molecular processes are very similar to the physiological response caused by exposure to altitude, the use of
 artificial hypoxia devices (systemic simulated hypoxia) or the delivery of vascular occlusion to the extremities
(also called local hypoxia by the blood flow restriction technique). “Tumor hypoxia” has gained further clinical
importance due to its crucial role in both tumor progression and resistance to treatment. However, the ability to
 manipulate this pathway through physical exercise and systemic hypoxia-mediated signalling pathways could
 offer an important range of therapeutic opportunities that should be further investigated. This review is focused
on the role of systemic hypoxia combined with exercise as a potential therapeutic proposal in digestive system
 neoplasms. We conclude that there is evidence that exercise performed under hypoxic conditions can improve
digestive system cancers modulating prognosis and quality of life, which could be considered as a potential new
 intervention in digestive oncological population.},
publisher = {Springer Nature},
keywords = {Aerobic exercise},
keywords = {Cell hypoxia},
keywords = {Digestive system neoplasms},
title = {Exercise under hypoxic condition as a potential therapeutic paradigm for digestive system cancers: A narrative review},
doi = {10.1007/s00432-022-03918-1},
author = {Pérez Regalado, Sergio and León, Josefa and Feriche Fernández-Castanys, María Belén},
}