@misc{10481/94920,
year = {2006},
month = {6},
url = {https://hdl.handle.net/10481/94920},
abstract = {Repetitive antigen stimulation induces peripheral T cell tolerance in vivo. It is notknown, however, whether multiple stimulations merely suppress T cell activation or,alternatively, change the transcriptional program to a distinct, tolerant state. In thisstudy, we have discovered that STAT3 and STAT5 were activated in response to antigenstimulation in vivo, in marked contrast to the suppression of AP-1, NF-jB and NFAT. Inaddition, a number of transcription factors were induced in tolerant T cells followingantigen challenge in vivo, including T-bet, Irf-1 and Egr-2. The altered transcriptionprogram in tolerant cells associates closely with the suppression of cell cycle progressionand IL-2 production, as well as with the induction of IL-10. Studies of T-bet and Egr-2show that the function of T-bet in peptide treatment-induced regulatory T cells is notassociated with Th1 differentiation, but correlates with the suppression of IL-2, whereasexpression of Egr-2 led to an up-regulation of the cell cycle inhibitors p21 cip1 and p27 kip .Our results demonstrate a balanced transcription program regulated by differenttranscription factors for T cell activation and/or tolerance during antigen-induced T cellresponses. Persistent antigen stimulation can induce T cell tolerance by changing thebalance of transcription factors.},
organization = {Wellcome Trust},
organization = {Swedish Strategic Research fund},
organization = {Barts Foundation for Research},
organization = {Brunel University},
publisher = {Wiley},
keywords = {T cell tolerance},
keywords = {STAT3},
keywords = {STAT5},
title = {Persistent antigenic stimulation alters the transcriptionprogram in T cells, resulting in antigen-specific tolerance},
doi = {10.1002/eji.200635883},
author = {Anderson, Per Olof and Manzo, Barbara and Sundstedt, Anette and Minaee, Sophie and Symonds, Alistair and Khalid, Sabah and Rodríguez Cabezas, María Elena and Nicolson, Kirsty and Li, Suling and Wraith, David C. and Wang, Ping},
}