@misc{10481/94756,
year = {2024},
month = {1},
url = {https://hdl.handle.net/10481/94756},
abstract = {Although ADHD is one of the most prevalent diseases during childhood, we still do not
know its precise origin; oxidative/nitrosative stress and the hypothalamic–pituitary–adrenal axis are
suggested contributors. Methylphenidate, among others, is the main drug used in ADHD patients,
but its effects on relevant markers and structures remain unclear. This study, involving 59 patients
diagnosed with ADHD according to DSM-5 criteria, aimed to assess changes in cortisol levels (using
cortisol awakening response, CAR) and oxidative/nitrosative status with the treatment. Blood
samples before and 3 months after treatment with methylphenidate were used to measure oxidative
and inflammatory markers, as well as the endogenous antioxidant activity, while saliva samples
tracked cortisol awakening response (CAR). The results showed a treatment-related improvement
in the redox profile, with the reduction in advanced oxidation protein products (AOPP), lipid
peroxidation (LPO), and nitrite plus nitrate (NOx) levels, and the increase in the enzymatic activities
of glutathione reductase (GRd) and catalase (CAT). Moreover, the area under the curve (AUC) of
CAR increased significantly, indicating increased reactivity of the HPA axis. These results support,
for the first time, the involvement of the endogenous antioxidant system in the pathophysiology
of ADHD.},
organization = {Instituto de Salud Carlos III through the project CB/10/00238 (Co-funded by European Regional Development Fund/European Social Fund “Investing in your future”)},
organization = {Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (CTS-101), Spain},
organization = {UGC de Laboratorios Clínicos, Hospital Universitario San
Cecilio, Granada, Spain},
publisher = {MDPI},
keywords = {Attention deficit hyperactivity disorder (ADHD)},
keywords = {Oxidative stress},
keywords = {Inflammation},
title = {Changes in Cortisol and in Oxidative/Nitrosative Stress Indicators after ADHD Treatment},
doi = {10.3390/antiox13010092},
author = {Garre Morata, Laura and Haro Muñoz, Tomás de and González-Villén, Raquel and Fernández López, María Luisa and Escames Rosa, Germaine and Molina Carballo, Antonio and Acuña Castroviejo, Darío},
}