@misc{10481/94603,
year = {2020},
month = {8},
url = {https://hdl.handle.net/10481/94603},
abstract = {Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators
of many key cellular events such as proliferation, di erentiation, cell cycle regulation, migration,
or apoptosis. To control these biological responses, GTPases activity is regulated by guanine nucleotide
exchange factors (GEFs), GTPase activating proteins (GAPs), and in some small GTPases also guanine
nucleotide dissociation inhibitors (GDIs). Moreover, small GTPases transduce signals by their
downstream e ector molecules. Many studies demonstrate that small GTPases of the Ras family are
involved in neurodegeneration processes. Here, in this review, we focus on the signaling pathways
controlled by these small protein superfamilies that culminate in neurodegenerative pathologies,
such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Specifically, we concentrate on
the two most studied families of the Ras superfamily: the Ras and Rho families. We summarize
the latest findings of small GTPases of the Ras and Rho families in neurodegeneration in order to
highlight these small proteins as potential therapeutic targets capable of slowing down di erent
neurodegenerative diseases.},
organization = {predoctoral fellowship (PRE_2017_1_0016) from the Basque Government},
organization = {Foundation “Jesús de Gangoiti y Barrera”},
organization = {Instituto de Salud Carlos III (PI18/00207) and the University of Basque Country Grant (US19/04)},
publisher = {MDPI},
keywords = {GTPases},
keywords = {neurodegeneration},
keywords = {Alzheimer},
title = {Small GTPases of the Ras and Rho Families Switch on/o  Signaling Pathways in Neurodegenerative Diseases},
doi = {10.3390/ijms21176312},
author = {Arrazola Sastre, Alazne and Luque Montoro, Miriam and Gálvez Martín, Patricia and M Lacerda, Hadriano and Lucía, Alejandro and Llavero, Francisco and Zugaza, José Luis},
}