@misc{10481/94519,
year = {2021},
month = {12},
url = {https://hdl.handle.net/10481/94519},
abstract = {A supported gold nanoparticle-catalyzed strategy has been utilized to promote a click chemistry
reaction for the synthesis of 1,2,3-triazoles via the azide-alkyne cycloaddition (AAC) reaction.
While the advent of effective non-copper catalysts (i.e., Ru, Ag, Ir) has demonstrated the catalysis of
the AAC reaction, additional robust catalytic systems complementary to the copper catalyzed AAC
remain in high demand. Herein, Au nanoparticles supported on Al2O3, Fe2O3, TiO2 and ZnO, along
with gold reference catalysts (gold on carbon and gold on titania supplied by theWorld Gold Council)
were used as catalysts for the AAC reaction. The supported Au nanoparticles with metal loadings of
0.7–1.6% (w/w relative to support) were able to selectively obtain 1,4-disubstituted-1,2,3-triazoles in
moderate yields up to 79% after 15 min, under microwave irradiation at 150  C using a 0.5–1.0 mol%
catalyst loading through a one-pot three-component (terminal alkyne, organohalide and sodium
azide) procedure according to the “click” rules. Among the supported Au catalysts, Au/TiO2 gave
the best results.},
organization = {Fundação para a Ciência e a Tecnologia (FCT), Portugal, through
project UIDB/00100/2020 of Centro de Química Estrutural},
organization = {FCT, under the Scientific Employment Stimulus-Institutional Call (CEECINST/00102/2018)},
organization = {Associate Laboratory for Green Chemistry—LAQV financed by national funds fromFCT/MCTES (UIDB/50006/2020 and UIDP/50006/2020) and Base-UIDB/50020/2020 and
Programmatic-UIDP/50020/2020 funding of the Associate Laboratory LSRE-LCM},
organization = {CATSUS Ph.D. Program for her grant (PD/BD 135555/2018)},
organization = {Instituto Superior
Técnico, Portugal, through the project CO2usE-1801P.00867.1.01 (contract no. IST-ID/263/2019).},
organization = {RUDN University Strategic Academic Leadership Program},
publisher = {MDPI},
keywords = {Au nanoparticles},
keywords = {supported catalysts},
keywords = {azide-alkyne},
title = {Heterogeneous Gold Nanoparticle-Based Catalysts for the Synthesis of Click-Derived Triazoles via the Azide-Alkyne Cycloaddition Reaction},
doi = {10.3390/catal12010045},
author = {L. Librando, Ivy and G. Mahmoud, Abdallah and C. Carabineiro, Sónia A. and C. Guedes da Silva, M. Fátima and Maldonado-Hódar, Francisco J. and G. C. Geraldes, Carlos F. and L. Pombeiro, Armando J.},
}