@misc{10481/94466,
year = {2022},
month = {5},
url = {https://hdl.handle.net/10481/94466},
abstract = {This study investigated the vasoactive effects of des-aspartate-angiotensin-I (DAA-I) in
male Wistar rats on whole body vascular bed, isolated perfused kidneys, and aortic rings. Dose–
response curves to DAA-I were compared with those to angiotensin II (Ang II). The Ang II-type-1
(AT1) receptor blocker, losartan, was used to evaluate the role of AT1 receptors in the responses
to DAA-I. Studies were also conducted of the responsiveness in aortic rings after endothelium
removal, nitric oxide synthase inhibition, or AT2 receptor blockade. DAA-I induced a dose-related
systemic pressor response that was shifted to the right compared with Ang II. Losartan markedly
attenuated the responsiveness to DAA-I. DAA-I showed a similar pattern in renal vasculature
and aortic rings. In aortic rings, removal of endothelium and nitric oxide inhibition increased the
sensitivity and maximal response to DAA-I and Ang II. AT2 receptor blockade did not significantly
affect the responsiveness to DAA-I. According to these findings, DAA-I increases the systemic
blood pressure and vascular tone in conductance and resistance vessels via AT1 receptor activation.
This vasoconstrictor effect of DAA-I participates in the homeostatic control of arterial pressure,
which can also contribute to the pathogenesis of hypertension. DAA-I may therefore be a potential
therapeutic target in cardiovascular disease.},
organization = {Carlos III Health Institute of Spain grant number
PI18/01715 and the Cooperative Research Network RICORS2040, RD21/0005/0015 “FEDER a way
to make Europe”},
publisher = {MDPI},
keywords = {renin-angiotensin system},
keywords = {des-aspartate-angiotensin I},
keywords = {vascular reactivity},
title = {Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat},
doi = {10.3390/biomedicines10061230},
author = {Wangensteen, Rosemary and Gómez Guzmán, Manuel and Banegas, Inmaculada and Rodríguez-Gómez, Isabel and Jiménez, Rosario and Duarte, Juan and García-Estañ, Joaquín and Vargas, Félix},
}