@misc{10481/94393,
year = {2024},
month = {9},
url = {https://hdl.handle.net/10481/94393},
abstract = {Gastrointestinal cancer is one of the greatest challenges for biomedical research, accounting
for one-quarter of diagnoses and one-third of deaths nowadays, due to the existence of drug resistance
mechanisms that prevent therapeutic efficacy in advanced stages. Nanotechnology has been shown
to be an effective strategy for the evasion of this phenomenon, and gene silencing by siRNA makes
it possible to decrease the expression of certain genes involved in chemoresistance and tumor
progression. Our review analyzed studies published during the last 5 years that combined siRNA
gene inhibition and chemotherapy as treatment of different gastrointestinal tumors. This review was
carried out by searching PubMed, SCOPUS andWoS databases, where 49 articles were finally selected.
The results showed that simultaneous encapsulation of siRNA targeting different genes involved in
cancer and chemotherapy were more effective at the preclinical level compared to the administration
of both treatments individually. The cytotoxic effect was generated through increased induction of
apoptosis derived from the dysregulation of chemoresistance-related pathways, producing a decrease
in tumor volume and an increase in survival of mice in in vivo assays. Therefore, the combination of
both therapies in the same nanoformulation appears to be an interesting therapeutic strategy for the
treatment of gastrointestinal tumors.},
organization = {Personalized Medicine and Advanced Therapies
Program (PMPTA22/00136), Instituto de Salud Carlos III},
publisher = {MDPI},
keywords = {Nanotechnology},
keywords = {Gastrointestinal cancer},
keywords = {siRNA},
title = {Nanoparticles Combining Gene Therapy and Chemotherapy as a Treatment for Gastrointestinal Tumors: A Systematic Review},
doi = {10.3390/app14177872},
author = {Rodríguez Criado, Jorge and Quiñonero Muñoz, Francisco José and Prados Salazar, José Carlos and Melguizo Alonso, Consolación},
}