@misc{10481/94382,
year = {2022},
month = {12},
url = {https://hdl.handle.net/10481/94382},
abstract = {Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide.
Despite the advances and success of current treatments (e.g., chemotherapy), there are multiple
serious side effects which require the development of new treatment strategies. In recent years, fungi
have gained considerable attention as a source of extracts and bioactive compounds with antitumor
capabilities because of their antimicrobial and antioxidant properties and even their anti-inflammatory
and antiviral activities. In the present review, a systematic search of the existing literature in four
electronic databases was carried out in which the antitumor activity against CRC cells of Ascomycota
fungi extracts or compounds was tested. The systematical research in the four databases resulted
in a total of 883 articles. After applying exclusion and inclusion criteria, a total of 75 articles were
finally studied. The order Eurotiales was the most studied (46% of the articles), and the ethyl acetate
extraction was the most used method (49% of the papers). Penicillium extracts and gliotoxin and
acetylgliotoxin G bioactive compounds showed the highest cytotoxic activity. This review also focuses
on the action mechanisms of the extracts and bioactive compounds of fungi against CRC, which were
mediated by apoptosis induction and the arrest of the cell cycle, which induces a notable reduction in
the CRC cell proliferation capacity, and by the reduction in cell migration that limits their ability to
produce metastasis. Thus, the ability of fungi to induce the death of cancer cells through different
mechanisms may be the basis for the development of new therapies that improve the current results,
especially in the more advanced stages of the CCR.},
organization = {Project P20_00540 (Proyectos I+D+i Junta de
Andalucía 2020), PYC20 RE 035, and P18-TP-1420 (Junta de Andalucía) and Innbio INB-009 (Granada
University and ibs. GRANADA)},
organization = {P-FIS (2020) and FPU (2019)
grant from the Instituto de Salud Carlos III and Ministerio de Educación, Ciencia y Deporte y
Competitividad (Spain)},
publisher = {MDPI},
keywords = {colorectal cancer},
keywords = {Ascomycota},
keywords = {bioactive compounds},
title = {In Vitro Efficacy of Extracts and Isolated Bioactive Compounds from Ascomycota Fungi in the Treatment of Colorectal Cancer: A Systematic Review},
doi = {10.3390/ph16010022},
author = {Luque, Cristina and Cepero, Ana and Perazzoli, Gloria and Mesas Hernández, Cristina and Quiñonero Muñoz, Francisco José and Cabeza Montilla, Laura and Prados Salazar, José Carlos and Melguizo Alonso, Consolación},
}