@misc{10481/93671,
year = {2024},
month = {5},
url = {https://hdl.handle.net/10481/93671},
abstract = {Citrulline (C6H13N3O3) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a terminal ureido group on its aliphatic chain, which also appears to coordinate. Here, two new mixed complexes of citrulline were made with 1,10-phenanthroline and 2,2′-bipyridine. These compounds, once dissolved in water, gave aquo-complexes that were subject to DFT studies and in vitro toxicity studies on cancer cell lines (HeLa, MDA-MB-231, HCT 15, and MCF7) showed promising results. Docking studies with DNA were also conducted, indicating potential anticancer properties.},
organization = {Project 100108444-VIEP, 100256733-VIEP},
organization = {Project 100233622-
VIEP},
organization = {PRODEP Academic Group BUAP-CA-263 (SEP, Mexico)},
organization = {Ministerio de Universidades
and Funds Next-Generation for the Margarita Salas contract 401 (Spain)},
publisher = {MDPI},
keywords = {citrulline},
keywords = {anticancer},
keywords = {mixed-copper complexes},
title = {L-Citrullinato-Bipyridine and L-Citrullinato-Phenanthroline Mixed Copper Complexes: Synthesis, Characterization and Potential Anticancer Activity},
doi = {10.3390/pharmaceutics16060747},
author = {Ramírez Contreras, Diego and Vázquez Rodríguez, Sergio and García García, Amalia and Noriega, Lisset and Mendoza, Angel and Sánchez-Gaytán, Brenda L. and Meléndez, Francisco J. and Castro, María Eugenia and Cárdenas-García, Maura and González-Vergara, Enrique},
}