@misc{10481/93592,
year = {2024},
month = {6},
url = {https://hdl.handle.net/10481/93592},
abstract = {Currently, there is an increase in the aging of the population, which represents a risk factor
for many diseases, including sarcopenia. Sarcopenia involves progressive loss of mass, strength,
and function of the skeletal muscle. Some mechanisms include alterations in muscle structure, reduced
regenerative capacity, oxidative stress, mitochondrial dysfunction, and inflammation. The
zebrafish has emerged as a new model for studying skeletal muscle aging because of its numerous
advantages, including histological and molecular similarity to human skeletal muscle. In this study,
we used fish of 2, 10, 30, and 60 months of age. The older fish showed a higher frailty index with a
value of 0.250 ± 0.000 because of reduced locomotor activity and alterations in biometric measurements.
We observed changes in muscle structure with a decreased number of myocytes
(0.031 myocytes/μm2 ± 0.004 at 60 months) and an increase in collagen with aging up to 15%
± 1.639 in the 60-month group, corresponding to alterations in the synthesis, degradation, and
differentiation pathways. These changes were accompanied by mitochondrial alterations, such as a
nearly 50% reduction in the number of intermyofibrillar mitochondria, 100% mitochondrial damage,
and reduced mitochondrial dynamics. Overall, we demonstrated a similarity in the aging processes
of muscle aging between zebrafish and mammals.},
organization = {CB16-10-00238 (ISCIII, Co-funded by European
Regional Development Fund/European Social Fund “Investing in your future”)},
organization = {P18-RT-698
(Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidad)},
publisher = {MDPI},
keywords = {zebrafish},
keywords = {aging},
keywords = {skeletal muscle},
title = {Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty},
doi = {10.3390/ijms25116166},
author = {Aranda Martínez, Paula and K. A. Sayed, Ramy and Fernández-Martínez, José and Ramírez Casas, Yolanda and Yang, Yang and Escames Rosa, Germaine and Acuña Castroviejo, Darío},
}