@misc{10481/93572,
year = {2024},
month = {6},
url = {https://hdl.handle.net/10481/93572},
abstract = {Background: Children with overweight/obesity often exhibit alterations in
their plasma protein profiles and reduced heart rate variability (HRV). Plasma
proteomics is at the forefront of identifying biomarkers for various clinical conditions.
We aimed to examine the association between plasma-targeted proteomics
involved in cardiovascular health and resting vagal-related HRV
parameters in children with overweight/obesity.
Methods: Forty-four children with overweight/obesity (10.2 ± 1.1 years old;
52% boys) participated in the study. Olink's technology was used to quantify
92 proteins involved in cardiovascular health. HRV was measured using a
heart rate monitor (Polar RS800CX). Four resting vagal-related HRV parameters
were derived in time- and frequency-domain.
Results: Eight proteins (KIM1, IgG Fc receptor II-b, IDUA, BOC, IL1RL2,
TNFRSF11A, VSIG2, and TF) were associated with at least one out of the four
vagal-related HRV parameters (β values ranging from  0.188 to 0.288; all
p < .05), while KIM1, IDUA, and BOC associated with ≥ three vagal-related
HRV parameters. Multiple hypothesis testing corrections did not reach statistical
significance (false discovery rate [FDR >0.05]). Conclusion: Plasma-targeted proteomics suggested novel biomarkers for resting
vagal-related HRV parameters in children with overweight/obesity. Future
studies using larger cohorts and longitudinal designs should confirm our findings
and their potential clinical implications.},
organization = {Spanish Ministry of Economy and
Competitiveness, Grant/Award Numbers:
DEP2013-47540, DEP2016-79512-R,
DEP2017-91544-EXP},
organization = {Andalusian
Operational Programme supported with
European Regional Development Funds},
organization = {Junta de Andalucia, Grant/Award
Number: P20_00158; PERC Systems
Biology Fund;},
organization = {Spanish Ministry of
Science, Innovation and Universities,
Grant/Award Number: FPU 22/02476},
organization = {Unit of Excellence on EXERNET Research
Network on Exercise and Health,
Grant/Award Numbers: DEP2005- 00046/
ACTI, 09/UPB/19, 45/UPB/20, 27/UPB/21},
organization = {University of Granada,
Grant/Award Number: SOMM17/6107/
UGR; MCIN/AEI/10.13039/501100011033,
Grant/Award Number: FJC2020-044453-I},
organization = {Universidad de Granada/CBUA},
publisher = {Wiley Online Library},
title = {Targeted proteomics involved in cardiovascular health and heart rate variability in children with overweight/obesity},
doi = {10.1002/ajhb.24113},
author = {Plaza-Florido, Abel and Olvera-Rojas, Marcos and A. Alcantara, Juan M. and Radom-Aizik, Shlomit and B. Ortega, Francisco},
}