@misc{10481/93547,
year = {2024},
month = {5},
url = {https://hdl.handle.net/10481/93547},
abstract = {Sex and thyroid hormones are critical for male reproductive health. However, the associations between haloacetic acid (HAA) exposure – a known endocrine disruptor – and sex and thyroid hormones in humans remains unclear. We thus recruited 502 male participants seeking fertility evaluation from a reproductive center. We measured concentrations of sex and thyroid hormones in a single blood sample and dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) in repeated urine samples. Multivariable linear regression models were constructed to evaluate the associations between HAA concentrations and hormone measurements. After adjusting for potential confounders and urinary creatinine concentrations, urinary concentrations of TCAA were inversely associated with serum levels of sex hormone-binding globulin (SHBG), testosterone (T), T/luteinizing hormone ratio (T/LH), and thyroid stimulating hormone (TSH) (all P for trend < 0.10). Compared with participants in the lowest quartile of TCAA concentrations, those in the highest quartile had reduced serum levels of SHGB by 14.2 % (95% CI: −26.7, −3.0 %), T by 11.1 % (95% CI: −21.7, −1.3 %), T/LH by 21.0 % (95% CI: −36.7, −7.1 %), and TSH by 19.1 % (95% CI: −39.7, −1.5 %). Additionally, we observed inverse associations between continuous measurements of urinary HAAs and serum levels of free T, bioactive T, and estradiol. Our findings suggest that male HAA exposure may be associated with disrupted sex and thyroid function.},
organization = {National Natural Science Foundation of
China (81903281)},
organization = {Guangzhou Basic and
Applied Basic Research Project (SL2023A04J02159)},
organization = {National Institute of Environmental Health
Sciences of the National Institutes of Health under Award Number
R01ES031657},
publisher = {Elsevier},
keywords = {Disinfection by-products},
keywords = {Haloacetic acid},
keywords = {Sex hormones},
title = {Urinary haloacetic acid concentrations in relation to sex and thyroid hormones among reproductive-aged men},
doi = {10.1016/j.envint.2024.108785},
author = {Chen, Ying-Jun and Messerlian, Carmen and Lu, Qi and Mustieles Miralles, Vicente and Zhang, Yu and Sun, Yang and Wang, Liang and Lu, Wen-Qing and Liu, Chong and Wang, Yi-Xin},
}