@misc{10481/93532,
year = {2020},
url = {https://hdl.handle.net/10481/93532},
abstract = {Background: Anecdotal evidence suggests a substantial proportion of individuals with cocaine use
disorder do not report craving during inpatient detoxification.
Objective: To examine prevalence and clinical correlates of consistent absence of cocaine craving
among inpatients during detoxification. We hypothesized that craving absence would be associated
with less severity of cocaine use, depression, and anxiety. Alternative explanations were also explored.
Methods: Craving absence (i.e., non-cravers) was defined as a daily score of zero across two separate
craving visual analogue scales in each of the inpatient days. Participants scoring ≥1 on ≥1 day were
considered cravers. Severity of cocaine use disorder as well as in-treatment depression and anxiety
were assessed. Alternative contributors included presence of cocaine and other substances in urine
at admission, in-treatment prescription of psychotropic medications, treatment motivation, executive
function, interoception, and social desirability.
Results: Eighty-seven participants (78.2% males) met criteria as either non-cravers (n = 29; 33.3%) or
cravers (n = 58; 66.7%). Mean length of admission in non-cravers and cravers was, respectively, 10.83
and 13.16 days. Binary logistic regression model showed that non-cravers scored significantly lower
than cravers on cocaine use during last month before treatment (OR, 95% CI; 0.902, 0.839–0.970), intreatment
depression (OR, 95% CI; 0.794, 0.659–0.956), and in-treatment prescribing of antipsychotics
(OR, 95% CI; 0.109, 0.014–0.823). Model prediction accuracy was 88.9%.
Conclusions: One in three patients undergoing inpatient detoxification experienced absence of craving,
linked to less pretreatment cocaine use, better mood, and decreased administration of antipsychotics.
Findings may inform pretreatment strategies and improve treatment cost-effectiveness.},
organization = {This study was supported by the Instituto de Salud Carlos III
(Spanish Ministry of Science, Innovation and Universities)
through Grant PI12/00105 from the Fondo de Investigación
Sanitaria and the RETICS (Red de Trastornos Adictivos)
Program.},
publisher = {TAYLOR & FRANCIS INC},
keywords = {Cocaine},
keywords = {Craving course},
keywords = {Urge},
keywords = {Withdrawal},
keywords = {Depression},
keywords = {Antipsychotics},
title = {Factors associated with the absence of cocaine craving in treatment-seeking individuals during inpatient cocaine detoxification.},
doi = {10.1080/00952990.2020.1833340},
author = {Pérez de los Cobos, José and Alcaraz, Saul and Verdejo-García, Antonio and Muñoz, Laura and Siñol, Nuria and Fernández-Serrano, María José and Fernández, Pilar and Martínez, Ana and Duran-Sindreu, Santiago and Batlle, Francesca and Trujols, Joan},
}