@misc{10481/93484,
year = {2024},
month = {5},
url = {https://hdl.handle.net/10481/93484},
abstract = {Background/objective: Major depressive disorder (MDD) is one of the leading causes of disease burden and
disability worldwide. Brain-derived neurotrophic factor (BDNF) seems to have an important role in the molecular
mechanisms underlying MDD aetiology, given its implication in regulating neuronal plasticity. There is evidence
that physical activity (PA) improves depressive symptoms, with a key role of BDNF in this effect. We aim to
perform a systematic review examining the relationship between the BDNF Val66Met polymorphism and the
BDNF protein, PA and MDD.
Methods: Both observational and experimental design original articles or systematic reviews were selected, according
to the PRISMA statement.
Results: Six studies evaluated the Val66Met polymorphism, suggesting a greater impact of physical activity on
depression depending on the Val66Met genotype. More discordant findings were observed among the 13 studies
assessing BDNF levels with acute or chronic exercise interventions, mainly due to the high heterogeneity found
among intervention designs, limited sample size, and potential bias.
Conclusions: Overall, there is cumulative evidence supporting the potential role of BDNF in the interaction between
PA and MDD. However, this review highlights the need for further research with more homogeneous and
standardised criteria, and pinpoints important confounding factors that must be considered in future studies to
provide robust conclusions.},
organization = {Spanish Ministry of Economy and
Competitiveness (BES-2017-082698)},
organization = {Spanish Ministry of Science and Innovation Juan
de la Cierva Incorporaci´on Program (grant code IJC2019-040080-I / AEI
/ 10.13039/501100011033) and Ram´on y Cajal Program (RYC2021-
034816-I)},
organization = {Ministry of Economy and Competitiveness and Institute of Health Carlos
III (FI19/00228)},
organization = {Operative Programme FEDER (B-CTS-256-UGR20)},
organization = {Universidad de Granada / CBUA},
publisher = {Elsevier},
keywords = {Major depression},
keywords = {Physical activity},
keywords = {Brain-derived neurotrophic factor},
title = {The relationship between BDNF and physical activity on depression},
doi = {10.1016/j.pnpbp.2024.111033},
author = {Zarza Rebollo, Juan Antonio and López Isac, Elena and Rivera Sánchez, Margarita and Gómez-Hernández, Laura and Pérez-Gutiérrez, Ana M. and Molina Rivas, Esther},
}