@misc{10481/93400,
year = {2024},
month = {5},
url = {https://hdl.handle.net/10481/93400},
abstract = {Two new lanthanide-complexes based on the 5-nitropicolinate ligand (5-npic) were obtained and fully characterized. Singlecrystal
X-ray diffraction revealed that these compounds are isostructural to a Dy-complex, previously published by us,
based on dinuclear monomers link together with an extended hydrogen bond network, providing a final chemical formula
of [
Ln2(5-npic)6(H2O)4]·(H2O)2, where Ln = Dy (1), Gd (2), and Tb (3). Preliminary photoluminescent studies exhibited a
ligand-centered emission for all complexes. The potential antitumoral activity of these materials was assayed in a prostatic
cancer cell line (PC-3; the 2nd most common male cancerous disease), showing a significant anticancer activity (50–60%
at 500 μg·mL−1). In turn, a high biocompatibility by both, the complexes and their precursors in human immunological
HL-60 cells, was evidenced. In view of the strongest toxic effect in the tumoral cell line provided by the free 5-npic ligand
(~ 40–50%), the overall anticancer complex performance seems to be triggered by the presence of this molecule.},
organization = {(RYC2021‐032522‐I)
funded by MCIN/AEI},
organization = {Ministerio de Universidades
and Next Generation for a Margarita Salas postdoctoral contract.
T.H.},
organization = {Multifunctional Metallodrugs
in Diagnosis and Therapy Network (MICIU, RED2018-102471-T).
T.H},
organization = {European Union’s Horizon 2020 Research and Innovation
Programme under the Marie Sklodowska-Curie grant agreement
No 897678 (NeuroMOF)},
organization = {Junta de Andalucía
(P20_01041)},
publisher = {Springer Nature},
keywords = {5-Nitropicolinic acid},
keywords = {Lanthanide},
keywords = {Coordination compounds},
title = {Potential antiprostatic performance of novel lanthanide‑complexes based on 5‑nitropicolinic acid},
doi = {10.1007/s00775-024-02054-0},
author = {García García, Amalia and Cristobal Cueto, Pablo and Hidalgo, Tania and Vitorica-Yrezabal, Iñigo Javier and Rodríguez Diéguez, Antonio and Horcajada, Patricia and Rojas Macías, Sara},
}