@misc{10481/93296,
year = {2022},
month = {4},
url = {https://hdl.handle.net/10481/93296},
abstract = {Objective: The HEPAFIT study was aimed at examining the impact of a 6-month physical
education intervention, considering various levels of exercise intensity, on hepatic fat and
cardiometabolic health outcomes in adolescents with excess adiposity.
Methods: Adolescents (11 to 17 years with excess adiposity by body fat >30%), were randomly
assigned to one of the following 4 groups for 6 months: (1) standard physical education lessons,
control (CTRL); (2) high-intensity physical education(HIPE); (3) low-to-moderate intensity
physical education(LIPE); (4) combined HIPE and LIPE(PLUS). The primary outcome was
hepatic fat content measured by vibration-controlled transient elastography (controlled
attenuation parameter [CAP]). Secondary outcomes were traditional cardiovascular health
markers (body composition, serum lipids, aminotransferases, and health-related physical fitness
components).
Results: Adjusted mixed effects linear models revealed a significant decrease in CAP levels in
HIPE (−13.81 dB/m,
p=0.030) (p=0.001 vs CTRL group) and PLUS (−22.41 dB/m,
p=0.001)
(p=0.002 vs CTRL group) groups. Body fat decreased in the HIPE, −1.47 %,
p<0.001) and
PLUS, −1.88 %,
p=0.001) groups. The physical fitness components were increased in the HIPE
and PLUS group relative to the baseline (p<0.05), and the HIPE group showed a reduction in the
total cholesterol (p<0.05).
Conclusions: Implementation of a 6-month physical education exercise program, particularly
high-intensity or combined high and low-intensity, improves hepatic fat storage and significantly
reduces cardiometabolic markers in adolescents with excess of adiposity. Interventions involving
supervised physical exercise may help to improve metabolism and fat deposition at the hepatic
level, thus preventing the development of non-alcoholic fatty liver disease in adolescents.
Trial Registration clinicaltrials.gov Identifier: NCT02753231},
organization = {The HEPAFIT Study was carried out with the financial support of Universidad del Rosario.
Katherine González-Ruíz received a scholarship from Universidad del Rosario, Colombia,
Escuela de Medicina y Ciencias de la Salud, to do a Doctorate. Robinson Ramírez-Vélez
training grant (ID420) as a post-doctoral research fellow with the Universidad Pública de
Navarra (UPNA). Mikel Izquierdo was supported by a research grant PI17/01814 of the
Ministerio de Economía, Industria y Competitividad (ISCIII, FEDER). Antonio GarcíaHermoso is a Miguel Servet Fellow (Instituto de Salud Carlos III-FSE – CP18/0150).},
title = {Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity},
doi = {10.1111/ijpo.12869},
author = {González-Ruíz, K and Correa-Bautista, JE and Izquierdo, M and García-Hermoso, A and Martínez-Vizcaíno, V and Lobelo, F and González-Jiménez, E and Schmidt Río Valle, Jacqueline and Correa-Rodríguez, M and Fernández-Irígoyen, J and Palomino-Echeverría, S and Santamaría, E and Ramírez-Vélez, R},
}