@misc{10481/92884, year = {2018}, url = {https://hdl.handle.net/10481/92884}, abstract = {Objective: To compare the clinical and histologic outcomes of two different grafting materials (allograft and xenograft) when combined with autogenous bone and covered with a collagen membrane for sinus augmentation. Material & Methods: A parallel case series of fourteen patients in need of a unilateral sinus augmentation was evaluated in this study. Seven patients received a graft composed by autologous cortical bone and anorganic bovine bone in a ratio of 1:1; the other seven patients received autologous cortical bone mixed with an allograft in the same ratio. Bone biopsies were obtained 6 months after sinus augmentation at the time of implant placement. Comparative histomorphometrical, histopathological and immunohistochemical analyses were conducted and statistically analyzed. Results: After 12 months of functional loading, all implants in both groups were clinical and radiographically successful. Histomorphometrically, although the initial bone formation was not significantly different between groups (new mineralized tissue: 41.03(12.87)% vs. 34.50(13.18)%, p=0.620; allograft vs. xenograft groups), the graft resorbed faster in the allograft group (remnant graft particles: 9.83(7.77)% vs. 21.71(17.88)%; p=0.026; allograft vs. xenograft groups). Non-mineralized tissue did not statistically differ either (49.00(14.32)% vs. 43.79(19.90)%; p=0.710; allograft vs. xenograft groups). The histologic analyses revealed higher cellular content, four times more osteoid lines and higher vascularization in the xenograft group. Musashi-1 (mesenchymal stromal cell marker) was also more intensively expressed in the xenograft group (p=0.019). Conclusions: Both composite grafts generate adequate substratum to receive dental implants after healing. Compared with the xenograft composite, allograft composite shows faster turnover and a quicker decrease in biological action after 6 months.}, organization = {The authors of this manuscript were partially supported by Research Groups #CTS-138 and #CTS-1028 (Junta de Andalucía, Spain). MPM is also supported by the Andalucía Talent Hub Program from the Andalusian Knowledge Agency (co-funded by the European Union’s Seventh Framework Program, Marie Skłodowska-Curie actions (COFUND – Grant Agreement nº 291780) and the Ministry of Economy, Innovation, Science and Employment of the Junta de Andalucía). This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.}, publisher = {Wiley}, keywords = {Maxillary sinus augmentation}, keywords = {Biomaterials}, keywords = {Anorganic bovine bone}, keywords = {Dental implants}, title = {Histopathological comparison of healing after maxillary sinus augmentation using xenograft mixed with autogenous bone versus allograft mixed with autogenous bone}, doi = {10.1111/clr.13029}, author = {Galindo Moreno, Pablo Antonio and González de Buitrago García, Juan Eladio and Padial Molina, Miguel and Fernández Barbero, Juan Emilio and Ata Ali, Javier and O'Valle Ravassa, Francisco Javier}, }