@misc{10481/92745,
year = {2024},
month = {6},
url = {https://hdl.handle.net/10481/92745},
abstract = {Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours are known as
tumour-associated macrophages (TAMs). These specialized immune cells play crucial roles in tumour growth,
angiogenesis, immune regulation, metastasis, and chemoresistance. TAMs encompass various subpopulations,
primarily classified into M1 and M2 subtypes based on their differentiation and activities. M1 macrophages,
characterized by a pro-inflammatory phenotype, exert anti-tumoural effects, while M2 macrophages, with an antiinflammatory
phenotype, function as protumoural regulators. These highly versatile cells respond to stimuli from
tumour cells and other constituents within the tumour microenvironment (TME), such as growth factors, cytokines,
chemokines, and enzymes. These stimuli induce their polarization towards one phenotype or another, leading to
complex interactions with TME components and influencing both pro-tumour and anti-tumour processes.
This review comprehensively and deeply covers the literature on macrophages, their origin and function as well
as the intricate interplay between macrophages and the TME, influencing the dual nature of TAMs in promoting
both pro- and anti-tumour processes. Moreover, the review delves into the primary pathways implicated in
macrophage polarization, examining the diverse stimuli that regulate this process. These stimuli play a crucial role
in shaping the phenotype and functions of macrophages. In addition, the advantages and limitations of current
macrophage based clinical interventions are reviewed, including enhancing TAM phagocytosis, inducing TAM
exhaustion, inhibiting TAM recruitment, and polarizing TAMs towards an M1-like phenotype. In conclusion, while
the treatment strategies targeting macrophages in precision medicine show promise, overcoming several obstacles
is still necessary to achieve an accessible and efficient immunotherapy.},
organization = {Short-Term Scientific Mission (STSM) CA21116
E-COST-Grant, 2023},
organization = {Award of EMBO Scientific Exchange Grant
10383, 2023},
organization = {KWF Dutch Cancer Society
grant#15305-1359 Consejería de Economía, Conocimiento, Empresas
y Universidad de la Junta de Andalucía},
organization = {European Regional Development
Fund (ERDF), ref. P18-FR-2470, from the Ministry of Science, Innovation and
Universities (ref. RTI 2018-101309-B-C22), from the Chair “Doctors Galera-Requena in cancer stem cell research” (CMC-CTS963)},
organization = {MCIN/AEI/10.13039/501100011033 and FEDER “Una manera de hacer
Europa” (grant number PID2022-140151OB-C22)},
organization = {Associazione Italiana
per la Ricerca sul Cancro AIRC},
organization = {The Bennink Foundation},
publisher = {BioMed Central},
keywords = {Tumour-associated macrophages},
keywords = {Cancer cell},
keywords = {Tumour microenvironment},
title = {Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy},
doi = {10.1186/s13045-024-01559-0},
author = {Toledo, Belén and Chen, Linrui Zhu and Paniagua Sancho, María and Marchal Corrales, Juan Antonio and Perán, Macarena and Giovannetti, Elisa},
}