@misc{10481/92518,
year = {2024},
month = {2},
url = {https://hdl.handle.net/10481/92518},
abstract = {A family of sustainable carbon catalysts with different chemical surface, active and selective for the synthesis of
benzodiazepine 1 (BDZ), from o-phenylendiamine (OPD) 2 and acetone 3, under mild conditions, is reported.
Catalysts were prepared by acids treatments with H2SO4 or H3PO4 of an activated carbon doped with ZnO at 3%
wt (N3Zn) and, subsequently, submitted to additional thermal treatment in air. Simultaneously to the ZnO
leaching, surface C-SO3 groups were generated by treatment of N3Zn with H2SO4 (N3Zn-S) whereas treatment
with H3PO4 led to C-PO3 functions (N3Zn-P sample). The thermal treatment partially removes the C-SO3 groups
(N3Zn-S-C sample) while C-PO3 functions were partially oxidized to C-OPO3 groups (N3Zn-P-C). Our results
suggest that these chemical surface modifications of the catalysts are key on catalytic performance, pointed out
the importance of the nature and distribution of acid sites at the surface. Remarkably, investigated carbon
catalysts (N3Zn-S samples) were more active than the NS catalyst obtained by direct treatment of AC with H2SO4,
this last mainly functionalized with C-OSO3 groups. Although the catalysts resulting of the H3PO4 treatment
showed both a similar activity, some differences on selectivity to BDZ 1 were observed, attributed to certain
specificity of P-functions at the surface depending on the acid strength of active sites and the reaction conditions.
These results were supported by DFT calculations.},
organization = {Universidad Francisco de Vitoria de
Madrid (Project Ref. FV2023-38)},
organization = {Projects ref. PID2021-126579OB-C31 and PID2021-126579OB-C32 from MCIN/AEI/10.13039/501100011033 and “ERDF A way of making Europe”},
organization = {MICIN/AEI/10.13039 /501100011033 and FSE “El
FSE invierte en tu futuro” for the Ramon y Cajal research contract},
publisher = {Elsevier},
keywords = {Acid carbon-based catalysts},
keywords = {Green synthesis},
keywords = {Benzodiazepines},
title = {Highly efficient carbon catalysts for the green synthesis of 1,5-benzodiazepines: Experimental and theoretical study},
doi = {10.1016/j.cattod.2024.114572},
author = {Godino Ojer, Marina and Ripoll Morales, Vanessa and Pastrana Martínez, Luisa María and Morales Torres, Sergio and Maldonado Hodar, Francisco José and Pérez Mayoral, Elena},
}