@misc{10481/92478,
year = {2024},
month = {4},
url = {https://hdl.handle.net/10481/92478},
abstract = {Epidemiological studies focusing on metal(oid) exposure and excess body weight among children show inconsistent results
and the influence of metal(loid) mixtures has been little studied. We aimed to explore the effect of 10 metal(loid)s, individually
and in combinations, on overweight and obesity among children aged 6–12. Urinary levels of these metal(oid)s
from 92 controls and 51 cases with overweight and obesity were analyzed. Metal(loid) levels were log-transformed and
categorized into tertiles according to the control group cutoff points. Two logistic regression models and weighted quantile
sum regressions (WQS) were run: model 1 adjusting for age, sex, creatinine, energy intake and physical activity and model
2 additionally adjusting for maternal education, rice and fish consumption. In the single metal(oid) exposure model, there
was a trend of significant negative association for urinary cobalt (Co), where children in the third tertile had lower odds of
present overweight and obesity than those in the first (Odds Ratio, OR = 0.43; 95% Confidence Interval, CI = 0.20–0.93).
Urinary chromium (Cr) levels were borderline-significant negatively associated with overweight and obesity (ORa = 1.70;
95% CI = 0.97–2.98). Molybdemun, Cr and Co had a major contribution to the inverse association between metal(loid)
mixture and overweight and obesity as well as lead, cadmium and total arsenic in the positive relationship. Our findings in
this explorative study suggested an inverse association of high urinary Co levels with overweight and obesity. Moreover,
metal(loid) mixture exposure may have influence on overweight and obesity with an important contribution of Co in the
potential negative effect.},
organization = {Funding for open access publishing: Universidad de Granada/CBUA.},
organization = {Project PI20/01278, funded by Instituto de Salud Carlos III (ISCIII)},
organization = {European Regional Development Fund (ERDF/FEDER)},
organization = {FEDER-Consejería de Salud y Familias},
organization = {Junta de Andalucía PE-0250–2019},
organization = {FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/Proyecto P18-RT-4247},
organization = {INTRAIBS-2021–02 funded by ibs.GRANADA},
publisher = {Springer Nature},
keywords = {Overweight},
keywords = {Obesity},
keywords = {Children},
title = {Metal (loid) Exposure and Overweight and Obesity in 6–12‑Year‑Old Spanish Children},
doi = {10.1007/s12403-024-00638-4},
author = {Salcedo Bellido, Inmaculada and Castillo Bueno, Helga and Olmedo Palma, Pablo and Gil Hernández, Fernando and Ocaña Peinado, Francisco and Rodrigo Conde Salazar, Lourdes T. and Rivas Velasco, Ana María},
}