@misc{10481/92372, year = {2024}, month = {3}, url = {https://hdl.handle.net/10481/92372}, abstract = {Cherry stems, prized in traditional medicine for their potent antioxidant and anti-inflammatory properties, derive their efficacy from abundant polyphenols and anthocyanins. This makes them an ideal option for addressing skin aging and diseases. This study aimed to assess the antioxidant and anti-inflammatory effects of cherry stem extract for potential skincare use. To this end, the extract was first comprehensively characterized by HPLC-ESI-qTOF-MS. The extract’s total phenolic content (TPC), antioxidant capacity, radical scavenging efficiency, and its ability to inhibit enzymes related to skin aging were determined. A total of 146 compounds were annotated in the cherry stem extract. The extract effectively fought against NO· and HOCl radicals with IC50 values of 2.32 and 5.4 mg/L. Additionally, it inhibited HYALase, collagenase, and XOD enzymes with IC50 values of 7.39, 111.92, and 10 mg/L, respectively. Based on the promising results that were obtained, the extract was subsequently gently integrated into a cosmetic gel at different concentrations and subjected to further stability evaluations. The accelerated stability was assessed through temperature ramping, heating-cooling cycles, and centrifugation, while the long-term stability was evaluated by storing the formulations under light and dark conditions for three months. The gel formulation enriched with cherry stem extract exhibited good stability and compatibility for topical application. Cherry stem extract may be a valuable ingredient for creating beneficial skincare cosmeceuticals.}, organization = {Project P18-TP-3589, funded by the Regional Ministry of Economy, Knowledge, Enterprise, and Universities of Andalusia}, organization = {Spanish Ministry of Science, Innovation, and Universities for the grant FPU22/01562}, organization = {Regional Ministry of Economy, Knowledge, Enterprise and Universities of Andalusia for the contract for Young Researchers (PAIDI) at the University of Granada}, organization = {Spanish Ministry of Science, Innovation, and Universities for the grant FPU21/02714}, organization = {Contract RYC2021-032119-I founded by MCIN/AEI/10.13039/501100011033 and NextGeneration EU/PRTR}, publisher = {MDPI}, keywords = {Cherry}, keywords = {Revalorization}, keywords = {By-products}, title = {Bioactive Compounds and Potential Health Benefits through Cosmetic Applications of Cherry Stem Extract}, doi = {10.3390/ijms25073723}, author = {García Villegas, Abigail and Fernández Ochoa, Álvaro and Alañón, María Elena and Rojas García, Alejandro and Arráez Román, David and Cádiz Gurrea, María de la Luz and Segura Carretero, Antonio}, }