@misc{10481/92252, year = {2024}, month = {3}, url = {https://hdl.handle.net/10481/92252}, abstract = {Content-Based Histopathological Image Retrieval (CBHIR) is a search technique based on the visual content and histopathological features of whole-slide images (WSIs). CBHIR tools assist pathologists to obtain a faster and more accurate cancer diagnosis. Stain variation between hospitals hampers the performance of CBHIR tools. This paper explores the effects of color normalization (CN) in a recently proposed CBHIR approach to tackle this issue. In this paper, three different CN techniques were used on the CAMELYON17 (CAM17) data set, which is a breast cancer data set. CAM17 consists of images taken using different staining protocols and scanners in five hospitals. Our experiments reveal that a proper CN technique, which can transfer the color version into the most similar median values, has a positive impact on the retrieval performance of the proposed CBHIR framework. According to the obtained results, using CN as a pre-processing step can improve the accuracy of the proposed CBHIR framework to 97% (a 14% increase), compared to working with the original images.}, organization = {European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 860627 (CLARIFY Project). CLoud ARtificial Intelligence For pathologY. DOI: 10.3030/860627}, publisher = {MDPI}, keywords = {Color}, keywords = {Histopathological images}, keywords = {Content Based Image Retrieval}, keywords = {Whole slide imaging}, title = {Advancing Content-Based Histopathological Image Retrieval Pre-Processing: A Comparative Analysis of the Effects of Color Normalization Techniques}, doi = {10.3390/app14052063}, author = {Tabatabaei, Zahra and Pérez Bueno, Fernando and Colomer, Adrián and Oliver Moll, Javier and Molina Soriano, Rafael and Naranjo, Valery}, }