@misc{10481/92135,
year = {2024},
month = {1},
url = {https://hdl.handle.net/10481/92135},
abstract = {Cold exposure activates brown adipose tissue (BAT) and potentially improves cardiometabolic health
through the secretion of signaling lipids by BAT. Here, we show that 2 h of cold exposure in young adults increases
the levels of omega-6 and omega-3 oxylipins, the endocannabinoids (eCBs) anandamide and docosahexaenoylethanolamine,
and lysophospholipids containing polyunsaturated fatty acids. Contrarily, it decreases
the levels of the eCBs 1-LG and 2-LG and 1-OG and 2-OG, lysophosphatidic acids, and
lysophosphatidylethanolamines. Participants overweight or obese show smaller increases in omega-6 and
omega-3 oxylipins levels compared to normal weight. We observe that only a small proportion (~4% on
average) of the cold-induced changes in the plasma signaling lipids are slightly correlated with BAT volume.
However, cold-induced changes in omega-6 and omega-3 oxylipins are negatively correlated with adiposity,
glucose homeostasis, lipid profile, and liver parameters. Lastly, a 24-week exercise-based randomized
controlled trial does not modify plasma signaling lipid response to cold exposure.},
organization = {Junta de Andalucía, Consejería de Transformación Económica, Industria, Conocimiento y Universidades Dirección
General de Investigación y Transferencia del Conocimiento (ref. P18-RT-4455, ref. SOMM17/6107/UGR, and DOC 01151) and European Regional
Development Funds (ERDF)},
organization = {Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393)},
organization = {PTA-12264, Retos de la Sociedad (DEP2016-79512-R)},
organization = {Spanish Ministry of Education (FPU19/01609)},
organization = {Fundación Iberoamericana de Nutrición (FINUT)},
organization = {Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022)},
organization = {AstraZeneca HealthCare Foundation},
organization = {University of Granada Plan Propio de Investigación 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEES)},
organization = {Chinese Scholarship Council fellowships (no. 201707060012 and no. 201607060017)},
organization = {Grant for the requalification of the Spanish university system from the Ministry of Universities of the Government of Spain, financed by the European Union, NextGeneration EU (María Zambrano program, reference RR_C_2021_04)},
publisher = {Elsevier},
title = {Cold-induced changes in plasma signaling lipids are associated with a healthier cardiometabolic profile independently of brown adipose tissue},
doi = {10.1016/j.xcrm.2023.101387},
author = {Jurado Fasoli, Lucas and Sanchez‑Delgado, Guillermo and Di, Xinyu and Yang, Wei and Kohler, Isabelle and Villarroya, Francesc and Aguilera García, Concepción María and Hankemeier, Thomas and Ruiz Ruiz, Jonatan and Martínez Téllez, Borja Manuel},
}