@misc{10481/92113,
year = {2024},
url = {https://hdl.handle.net/10481/92113},
abstract = {Adolescent binge alcohol drinking is a serious health concern contributing to adult alcohol abuse often associated with anxiety disorders. We have used adolescent intermittent ethanol (AIE) administration as a model of binge drinking in rats in order to explore its long-term effect on the basolateral amygdala (BLA) responsiveness to alcohol and anxiety-like behavior. AIE increased the number of BLA c-Fos positive cells in adult Wistar rats and anxiety-like behavior assessed by the open field test (OFT). Additionally, in adult female rats receiving AIE BLA over expression of miR-182 was found. Therefore, our results indicate that alcohol consumption during adolescence can lead to enduring changes in anxiety-like behavior and BLA susceptibility to alcohol that may be mediated by sex-dependent epigenetic changes. These results contribute to understanding the mechanisms involved in the development of alcohol use disorders (AUD) and anxiety-related disorders.},
organization = {This study was funded by the research projects PID2020-114269GB-I00 funded by MCIN/AEI/10.13039/501100011033 (MICIU, Spain), BSEJ.514.UGR20 (FEDER, Junta de Andalucía, Spain) and a pre-doctoral fellowship FPU18/05012 to AV-Á (MIU, Spain).},
publisher = {Elservier},
keywords = {Alcohol},
keywords = {Anxiety-like behavior},
keywords = {Basolateral amygdala},
keywords = {C-Fos},
keywords = {Epigenetic},
keywords = {microARN},
title = {Adolescent alcohol exposure modifies adult anxiety-like behavior and amygdala sensitivity to alcohol in rats: Increased c-Fos activity and sex-dependent microRNA-182 expression},
doi = {10.1016/j.pbb.2024.173741},
author = {Vázquez de Ágredos Martín Gil, Ana and Valero, Marta and Aparicio-Mescua, Teresa and García-Rodríguez, Raquel and Gámiz Ruiz, Fernando and Gallo Torre, Milagros},
}