@misc{10481/92081,
year = {2024},
month = {3},
url = {https://hdl.handle.net/10481/92081},
abstract = {Introduction: Treatment resistance poses a significant obstacle in oncology, especially in biliary tract
cancer (BTC) and pancreatic cancer (PC). Current therapeutic options include chemotherapy, targeted
therapy, and immunotherapy. Resistance to these treatments may arise due to diverse molecular
mechanisms, such as genetic and epigenetic modifications, altered drug metabolism and efflux, and
changes in the tumor microenvironment. Identifying and overcoming these mechanisms is a major
focus of research: strategies being explored include combination therapies, modulation of the tumor
microenvironment, and personalized approaches.
Areas covered: We provide a current overview and discussion of the most relevant mechanisms of
resistance to chemotherapy, target therapy, and immunotherapy in both BTC and PC. Furthermore, we
compare the different strategies that are being implemented to overcome these obstacles.
Expert opinion: So far there is no unified theory on drug resistance and progress is limited. To
overcome this issue, individualized patient approaches, possibly through liquid biopsies or single-cell
transcriptome studies, are suggested, along with the potential use of artificial intelligence, to guide
effective treatment strategies. Furthermore, we provide insights into what we consider the most
promising areas of research, and we speculate on the future of managing treatment resistance to
improve patient outcomes.},
organization = {Award of EMBO Scientific Exchange Grant ref.: 10383, 2023},
organization = {Consejería de Economía, Conocimiento, Empresas y Universidad de la Junta de Andalucía and European Regional Development Fund (ERDF), ref. P18-FR-2470, from the Ministry of Science, Innovation and Universities [ref. RTI 2018-101309-B-C22], and from the Chair “Doctors Galera-Requena in cancer stem cell
research” [CMC-CTS963].},
organization = {KWF Dutch
Cancer Society, Associazione Italiana per la Ricerca sul Cancro AIRC},
organization = {Bennink Foundation},
publisher = {Taylor & Francis Group},
keywords = {Biliary tract cancer},
keywords = {Chemoresistance},
keywords = {Chemotherapy},
title = {Treatment resistance in pancreatic and biliary tract cancer: molecular and clinical pharmacology perspectives},
doi = {10.1080/17512433.2024.2319340},
author = {Toledo, Belén and Deiana, Chiara and Scianò, Fabio and Brandi, Giovanni and Marchal Corrales, Juan Antonio and Perán, Macarena and Giovannetti, Elisa},
}