@misc{10481/91849,
year = {2024},
month = {3},
url = {https://hdl.handle.net/10481/91849},
abstract = {Broccoli has gained popularity as a highly consumed vegetable due to its nutritional and health properties. This study
aimed to evaluate the composition profile and the antioxidant capacity of a hydrophilic extract derived from broccoli byproducts, as
well as its influence on redox biology, Alzheimer’s disease markers, and aging in the Caenorhabditis elegans model. The presence of
glucosinolate was observed and antioxidant capacity was demonstrated both in vitro and in vivo. The in vitro acetylcholinesterase
inhibitory capacity was quantified, and the treatment ameliorated the amyloid-β- and tau-induced proteotoxicity in transgenic strains
via SOD-3 and SKN-1, respectively, and HSP-16.2 for both parameters. Furthermore, a preliminary study on aging indicated that the
extract effectively reduced reactive oxygen species levels in aged worms and extended their lifespan. Utilizing broccoli byproducts for
nutraceutical or functional foods could manage vegetable processing waste, enhancing productivity and sustainability while providing
significant health benefits.},
organization = {“Visiting
Scholars 2022” Program from the Universidad de Granada},
organization = {FEDER/Junta de Andalucía-Consejería de Economía y Conocimiento, Grant B-AGR-193-UGR18},
organization = {“Contratos-Puente”
funded by the Universidad de Granada},
organization = {FPU fellow with grant reference FPU2018/
05301 funded by MCIN/AEI/10.13039/501100011033 and
FSE “El FSE invierte en tu futuro″},
organization = {JdC-I postdoctoral contract with grant
reference IJC2020-043910-I, funded by NextGenerationEU},
publisher = {American Chemical Society},
keywords = {Sulfur compounds},
keywords = {Amyloid-β},
keywords = {Hyperphosphorylated tau},
title = {In Vitro and In Vivo Insights into a Broccoli Byproduct as a Healthy Ingredient for the Management of Alzheimer’s Disease and Aging through Redox Biology},
doi = {10.1021/acs.jafc.3c05609},
author = {Navarro Hortal, María Dolores and Romero Márquez, José Manuel and López Bascón, María Asunción and Sánchez González, Cristina and Xiao, Jianbo and Sumalla Cano, Sandra and Battino, Maurizio and Forbes Hernández, Tamara Yuliett and Quiles Morales, José Luis},
}