@misc{10481/91553,
year = {2023},
month = {12},
url = {https://hdl.handle.net/10481/91553},
abstract = {Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα) belongs to the nuclear receptor
(NR) family, and is a heme-binding component of the circadian clock that consolidates circadian oscillators. In
addition to repressing the transcription of multiple clock genes associated with circadian rhythms, NR1D1 has a wide
range of downstream target genes that are intimately involved in many physiopathological processes, including
autophagy, immunity, inflammation, metabolism and aging in multiple organs. This review focuses on the pivotal
role of NR1D1 as a key transcription factor in the gene regulatory network, with particular emphasis on the milestones
of the latest discoveries of NR1D1 ligands. NR1D1 is considered as a promising drug target for treating diverse
diseases and may contribute to research on innovative biomarkers and therapeutic targets for organ injury-related
diseases. Further research on NR1D1 ligands in prospective human trials may pave the way for their clinical application
in many organ injury-related disorders.},
organization = {National Natural Science Foundation of
China (82070422, 82200330)},
organization = {China Postdoctoral Science Foundation
(2023T160526 and 2022M722571)},
organization = {Research Plan Project of Shaanxi
Institute of Basic Science (22JHQ053)},
organization = {High-end Foreign Expert Introduction
Program of National Science and Technology (G2022040014L)},
organization = {Qinchuangyuan Traditional Chinese Medicine Innovation Research and
Development Transformation Project (2022-QCYZH-036)},
publisher = {BioMed Central},
keywords = {NR1D1},
keywords = {REV-ERBα},
keywords = {Circadian rhythms},
title = {Targeting NR1D1 in organ injury: challenges and prospects},
doi = {10.1186/s40779-023-00495-3},
author = {Zhang sun, Zi Yin and Xu, Xue Zeng and Escames Rosa, Germaine and Lei, Wang Rui and Zhao, Lin and Zhou, Ya Zhe and Tian, Ye and Ren, Ya‑Nan and Acuña Castroviejo, Darío and Yang, Yang},
}