@misc{10481/91119,
year = {2024},
month = {1},
url = {https://hdl.handle.net/10481/91119},
abstract = {In the context of the alarming rise of infant obesity and its health implications, the present
research aims to uncover disruptions in postprandial lipid metabolism and the composition of
triglyceride-rich lipoproteins in obese adolescents. A double-blind, controlled clinical trial in the postprandial
phase on 23 adolescents aged 12 to 16 years was carried out. Twelve participants were categorized
as obese (BMI > 30 kg/m2 and percentile > 95) and 11 as normal-weight (BMI = 20–25 kg/m2,
percentile 5–85). Blood samples were collected after a 12-h overnight fast and postprandially after
consumption of a standardized breakfast containing olive oil, tomato, bread, orange juice, and
skimmed milk. Obese adolescents exhibited elevated triglyceride concentrations in both fasting and
postprandial states and higher TG/apo-B48 ratios, indicating larger postprandial triglyceride-rich
lipoprotein (TRL) particle size, which suggests impaired clearance. Obese subjects also exhibited
higher n-6 PUFA concentrations, potentially linked to increased TRL hydrolysis and the release of
pro-inflammatory adipokines. In contrast, TRL from normal-weight individuals showed higher
concentrations of oleic acid and DHA (n-3 PUFA), with possible anti-inflammatory effects. The results
indicate an interplay involving postprandial TRL metabolism and adipokines within the context of
adolescent obesity, pointing to potential cardiovascular implications in the future.},
organization = {Spanish Ministry of Economy and Competitiveness (Grant
number AGL2011-23810)”},
organization = {“Next Generation EU” funds},
organization = {European Union Recovery, Transformation and Resilience Plan},
organization = {Ministry of Universities, in the framework of the Margarita Salas, Maria Zambrano grants for the Requalification of the Spanish University System 2021–2023, organized by the Pablo de Olavide University, Seville},
publisher = {MDPI},
keywords = {Obesity},
keywords = {Adolescence},
keywords = {Postprandial},
title = {Interplay of Postprandial Triglyceride-Rich Lipoprotein Composition and Adipokines in Obese Adolescents},
doi = {10.3390/ijms25021112},
author = {García Rodríguez, Silvia and Espinosa Cabello, Juan M. and García González, Aída and González Jiménez, Emilio and Aguilar Cordero, Josefa and Castellano, Jose M. and Perona, Javier S.},
}