@misc{10481/91036,
year = {2024},
month = {1},
url = {https://hdl.handle.net/10481/91036},
abstract = {The present narrative review summarizes recent findings focusing on the role of
brain-derived neurotrophic factor (BDNF) as a biomarker of effect for
neurodevelopmental alterations during adolescence, based on health effects of
exposure to environmental chemical pollutants. To this end, information was
gathered from the PubMed database and the results obtained in the European
project Human Biomonitoring for Europe (HBM4EU), in which BDNF was
measured at two levels of biological organization: total BDNF protein (serum) and
BDNF gene DNA methylation (whole blood) levels. The obtained information is
organized as follows. First, human biomonitoring, biomarkers of effect and the
current state of the art on neurodevelopmental alterations in the population are
presented. Second, BDNF secretion and mechanisms of action are briefly explained.
Third, previous studies using BDNF as an effect biomarker were consulted in PubMed
database and summarized. Finally, the impact of bisphenol A (BPA), metals, and nonpersistent
pesticide metabolites on BDNF secretion patterns and its mediation role
with behavioral outcomes are addressed and discussed. These findingswere obtained
from three pilot studies conducted in HBM4EU project. Published findings suggested
that exposure to some chemical pollutants such as fine particle matter (PM), PFAS,
heavy metals, bisphenols, and non-persistent pesticides may alter circulating BDNF
levels in healthy population. Therefore, BDNF could be used as a valuable effect
biomarker to investigate developmental neurotoxicity of some chemical pollutants.},
organization = {European Human Biomonitoring Initiative (HMB4EU) project supported financially by the European Union’s Horizon 2020 research and innovation program under grant agreements No’s 733032},
organization = {Partnership for the Assessment of Risks from Chemicals (PARC), supported financially by the European Union’s Horizon 2020 research and innovation program under grant agreements No’s 101057014},
organization = {Postdoctoral fellowship granted by the Fundación Ramón Areces (BEVP34P01A6845), Spain},
publisher = {Frontiers Media},
keywords = {Brain-derived neurotrophic factor},
keywords = {Neurodevelopment},
keywords = {Human biomonitoring},
title = {Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs},
doi = {10.3389/ftox.2023.1319788},
author = {Rodríguez Carrillo, Andrea and Verheyen, Veerle J. and Van Nuijs, Alexander L. N. and Fernández Cabrera, Mariana Fátima and Remy, Sylvie},
}