@misc{10481/90854,
year = {2024},
month = {2},
url = {https://hdl.handle.net/10481/90854},
abstract = {The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people.},
organization = {Catalan Department of Economy and Knowledge (SGR2017/1974, SGR2017/801)},
organization = {Spanish Ministry of Science  (MDM-2014-0370), (CEX2018-000806-S)},
organization = {Fondo Europeo de Desarrollo Regional, UE (RTI2018-100789-B-I00)},
organization = {Estonian Research Council (PUT1660)},
organization = {Instituto de Salud Carlos III (COV20_00622)},
organization = {European Union (ERDF)},
organization = {Amancio Ortega Foundation},
organization = {Banco de Santander},
organization = {Generalitat de Catalunya},
publisher = {Springer Nature},
title = {Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2},
doi = {10.1038/s42003-024-05805-6},
author = {Pérez-Jurado, Luis A. and Cáceres, Alejandro and Balagué-Dobón, Laura and Esko, Tonu and López de Heredia, Miguel and Quintela, Inés and Cruz, Raquel and Lapunzina, Pablo and Carracedo, Ángel and SCOURGE Cohort Group and González, Juan R.},
}