@misc{10481/90550,
year = {1999},
month = {2},
url = {https://hdl.handle.net/10481/90550},
abstract = {We studied the diagnostic reliability of a modification of the Enzygnost EBV test (Behringwerke, Germany) for the detection of IgG, IgA, and IgM antibodies (Abs) in the diagnosis of Epstein-Barr virus (EBV) disease. One hundred and twenty-three serum samples were studied: 14 asymptomatic subjects without EBV infection, 48 patients with primary infection, 46 subjects with past EBV infection (11 patients with other acute infections), 8 patients without EBV infection but with other viral infection, and 7 patients with probable acute clonal stimulation of B lymphocytes caused by different microorganisms. Enzygnost EBV is based on an ELISA test with a pool of viral antigens. In our series the reliability of IgM for the diagnosis of recent primary EBV infection was: sensitivity 100%, specificity 95%, positive predictive value 90.5%, and negative predictive value 100%. The IgG detection with Enzygnost was: sensitivity 98%, specificity 100%, positive predictive value 100%, and negative predictive value 91.7%. Only two subjects had positive IgA. The Enzygnost test is an efficient method for the diagnosis of EBV infection although a few IgM false positives can occur.},
publisher = {Wiley},
keywords = {Epstein-Barr virus},
keywords = {ELISA},
keywords = {Antibodies},
title = {Clinical Reliability of IgG, IgA, and IgM Antibodies in Detecting Epstein-Barr Virus at Different Stages of Infection With a Commercial Nonrecombinant Polyantigenic ELISA},
doi = {10.1002/(SICI)1098-2825(1999)13:2<65::AID-JCLA4>3.0.CO;2-O},
author = {Gutiérrez Fernández, José and Vergara, M.J. and Piédrola Angulo, Gonzalo and Maroto Vela, María del Carmen},
}