@misc{10481/90377,
year = {2023},
month = {11},
url = {https://hdl.handle.net/10481/90377},
abstract = {Context: The endocannabinoid system (ECS) is a signaling system composed of endocannabinoids (eCBs), their receptors, and the enzymes
involved in their synthesis and metabolism. Alterations in the ECS are linked to the development of cardiometabolic diseases.
Objective: Here, we investigated the relationship between plasma levels of eCBs and their analogues with body composition and
cardiometabolic risk factors.
Methods: The study included 133 young adults (age 22.1 ± 2.2 years, 67% women). Fasting plasma levels of eCBs and their analogues were
measured using liquid chromatography-tandem mass spectrometry. Body composition, brown adipose tissue (BAT) volume, glucose uptake,
and traditional cardiometabolic risk factors were measured.
Results: Plasma levels of eCBs and several eCB analogues were positively correlated with adiposity and traditional cardiometabolic risk factors (eg,
serum insulin and triacylglyceride levels, all r ≥ 0.17 and P ≤ .045). Plasma levels of 2-arachidonoyl glycerol and N-pentadecenoylethanolamine were
negatively correlated with BAT volume and glucose uptake (all r ≤ −0.17 and P ≤ .047). We observed that the plasma levels of eCBs and their
analogues were higher in metabolically unhealthy overweight–obese participants than in metabolically healthy overweight–obese participants.
Conclusion: Our findings show that the plasma levels of eCBs and their analogues are related to higher levels of adiposity and worse
cardiometabolic profile.},
organization = {Spanish Ministry of Economy
and Competitiveness via the Fondo de Investigación Sanitaria
del Instituto de Salud Carlos III (PI13/01393)},
organization = {Spanish Ministry of Economy
and Competitiveness (PTA-12264)},
organization = {Retos de la Sociedad (DEP2016-79512-R)},
organization = {European
Regional Development Fund (ERDF)},
organization = {Spanish Ministry of
Education (FPU16/02828, FPU17/01523 and FPU19/01609)},
organization = {Fundación Iberoamericana de Nutrición (FINUT)},
organization = {Redes Temáticas de Investigación Cooperativa RETIC
(Red SAMID RD16/0022)},
organization = {AstraZeneca HealthCare
Foundation},
organization = {University of Granada Plan Propio de
Investigación 2016 -Excellence actions: Unit of Excellence on
Exercise and Health (UCEES)},
organization = {Junta de Andalucía,
Consejería de Conocimiento, Investigación y Universidades
(ERDF; ref. SOMM17/6107/UGR and DOC 01151)},
organization = {Fundación Alfonso Martin Escudero},
organization = {Dutch Heart
Foundation, Dutch Federation of University Medical Centers},
organization = {Netherlands Organization for Health Research and
Development},
organization = {Royal Netherlands Academy of Arts and
Sciences (CVON2017-20 GENIUS-2)},
organization = {China Scholarship Council (no. 201707060012)},
publisher = {Oxford University Press},
keywords = {Body composition},
keywords = {Cardiometabolic risk factors},
keywords = {Anandamide},
title = {Higher Plasma Levels of Endocannabinoids and Analogues Correlate With a Worse Cardiometabolic Profile in Young Adults},
doi = {10.1210/clinem/dgad668},
author = {Di, Xinyu and Martínez Téllez, Borja Manuel and Krekels, Elke H.J. and Jurado Fasoli, Lucas and Osuna Prieto, Francisco Javier and Ortiz Álvarez, Lourdes and Hankemeier, Thomas and Rensen, Patrick C. N. and Ruiz Ruiz, Jonatan and Kohler, Isabelle},
}