@misc{10481/90028,
year = {2013},
month = {11},
url = {https://hdl.handle.net/10481/90028},
abstract = {Background: The primary test for the laboratory confirmation of measles is immunoglobulin M (IgM) serology. It is therefore important to evaluate new commercial measles IgM immunoassays to ensure high-quality measles diagnostic testing. The purpose of this study was to evaluate the diagnostic performance of LIAISON IgM measles (DiaSorin, Saluggia, Italy), a new automated chemiluminescence immunoassay (CLIA), in comparison with enzyme immunoassay (EIA) Enzygnost (Siemens, Marburg, Germany).

Methods: Sensitivity was examined using a panel of measles laboratory confirmed sera; specificity was addressed by testing sera from healthy populations and subjects with infections that may interfere with measles IgM serology.

Results: The diagnostic performances of the two assays were very similar: both Enzygnost EIA and LIAISON CLIA performed with a sensitivity of 93.7% and 98.8%, whereas the specificity was 96.8% and 97.9%, respectively.

Conclusion: We concluded that LIAISON IgM measles can be a good alternative to the other immunoassay for laboratory measles confirmation.},
publisher = {Wiley},
keywords = {Chemiluminescence},
keywords = {Measles},
keywords = {Serology},
title = {Comparative evaluation of a new chemiluminiscent assay and an ELISA for the detection of IgM against measles},
doi = {10.1002/jcla.21630},
author = {Sampedro, Antonio and Rodríguez-Granger, Javier and Gómez, Cristina and Lara, Ana and Gutiérrez Fernández, José and Otero, Ana},
}