@misc{10481/90020,
year = {2018},
month = {4},
url = {https://hdl.handle.net/10481/90020},
abstract = {Antecedentes y objetivos: Se analiza la presencia, a lo largo de los anos ˜ en infecciones urinarias, de aislados
de Escherichia coli y Klebsiella spp. productores de betalactamasa de espectro extendido (BLEE), y su
sensibilidad a antibióticos.
Material y método: Se realizó un estudio retrospectivo entre 2012 y 2016. La sensibilidad a ciproflo xacino, tobramicina, cefoxitina, fosfomicina, nitrofurantoína, cotrimoxazol y carbapenémicos se analizó
mediante el sistema MicroScan® .
Resultados: Se procesaron 95.399 muestras y se aislaron 9.772 E. coli, 1.784 Klebsiella pneumoniae y
248 Klebsiella oxytoca. Las cepas con BLEE fueron más frecuentes en mujeres, aunque disminuyó durante
2015 y 2016 (65,7-67,2%). La prevalencia de K. pneumoniae BLEE aumentó todos los anos ˜ (28,1% en el
2016). La prevalencia media de E. coli BLEE fue del 10,5%, con escasas oscilaciones. Las mayores resisten cias ocurrieron a ciprofloxacino y cotrimoxazol, 89,5 y 94,7% en 2015, respectivamente, y las menores a
imipenem. Fosfomicina y nitrofurantoína fueron muy activos sobre E. coli BLEE.
Conclusiones: E. coli y K. pneumoniae con BLEE fueron prevalentes y, sobre todo esta última, con una
importante resistencia a ciprofloxacino y cotrimoxazol. La sensibilidad a imipenem fue elevada},
abstract = {Background and objectives
A study of the susceptibility to antimicrobials of the extended spectrum beta-lactamase phenotypes (ESBL) in Escherichia coli and Klebsiella spp. was performed to discover the evolution of this type of resistance from urinary tract infections.

Material and method
A retrospective study was carried out between 2012 and 2016. Susceptibility to ciprofloxacin, tobramycin, cefoxitin, fosfomycin, nitrofurantoin, co-trimoxazole, and carbapenems was analyzed using MicroScan® system.

Results
A total of 95,399 samples were processed and 9,772 E. coli, 1,784 Klebsiella pneumoniae and 248 Klebsiella oxytoca were isolated. ESBL strains were more frequent in women, although they decreased during 2015 and 2016 (65.7-67.2%). The prevalence of K. pneumoniae ESBL increased annually (28.1% in 2016). The average prevalence of E. coli ESBL was 10.5% with few oscillations. Higher resistance occurred to ciprofloxacin and cotrimoxazole, 89.5 and 94.7% in 2015, respectively, and there was lesser resistance to imipenem. Fosfomycin and nitrofurantoin were very active on E. coli ESBL.

Conclusions
ESBL producing E. coli and K. pneumoniae were prevalent, especially the latter, with a significant resistance to ciprofloxacin and cotrimoxazole. Susceptibility to imipenem was high.},
publisher = {Elsevier},
keywords = {Infección del tracto urinario},
keywords = {Escherichia coli},
keywords = {Klebsiella pneumoniae},
keywords = {Klebsiella oxytoca},
keywords = {Antibióticos},
keywords = {Betalactamasa de espectro extendido},
keywords = {Urinary tract infection},
keywords = {Escherichia coli},
keywords = {Klebsiella pneumoniae},
keywords = {Klebsiella oxytoca},
keywords = {Antimicrobials},
keywords = {Extended spectrum beta-lactamase},
title = {Escherichia coli y Klebsiella pneumoniae productores de betalactamasa de espectro extendido en infecciones de vías urinarias: evolución de la resistencia antibiótica y opciones terapéuticas},
doi = {10.1016/j.medcli.2017.07.023},
author = {Jiménez-Guerra, Gemma and Heras-Cañas, Víctor and Béjar Molina, Lucía del Carmen and Sorlozano Puerto, Antonio and Navarro Marí, José María and Gutiérrez Fernández, José},
}