@misc{10481/89984,
year = {2002},
month = {6},
url = {https://hdl.handle.net/10481/89984},
abstract = {Background: A possible but as yet unproven relationship has been proposed between the onset or persistence of multiple sclerosis (MS) symptoms and herpesviruses, including, most recently, human herpesvirus 6 (HHV-6). A study was conducted to investigate the presence of HHV-6 DNA and the synthesis of antibodies against HHV-6, cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in serum and cerebrospinal fluid (CSF) of patients with MS.

Materials and methods: PCR and ELISA were used to detect HHV-6 DNA and specific antibodies against HHV-6, CMV and EBV in 211 samples (139 sera and 72 CSF). There were three groups of samples: group I, paired samples of serum and CSF from 41 MS patients; group II, paired samples of serum and CSF from 31 patients with neurological diseases other than MS (OND); group III, 67 serum samples from 27 different MS patients undergoing serologic follow-up.

Results: No HHV-6 DNA was found in any sample. Group I sera showed elevated anti-HHV-6 IgG and IgA levels. In group II, anti-CMV IgG was detected in one CSF sample and anti-HHV-6 IgM in one serum sample. Group III sera showed high concentrations of anti-HHV-6 IgG, IgA and IgM.

Conclusion: Given the clinical implications of the presence of antibodies against HHV-6 in MS patients, a viral reactivation cannot be excluded as an environmental factor.},
organization = {Health Council of Andalusian Regional Goverments, project 141/2001},
organization = {Spanish Federation of Multiple Sclerosis},
publisher = {Springer Nature},
keywords = {Herpesvirus},
keywords = {Multiple sclerosis},
keywords = {HHV-6},
keywords = {CMV},
keywords = {EBV},
title = {Multiple sclerosis and human herpesvirus 6},
doi = {10.1007/s15010-002-2056-7},
author = {Gutiérrez Fernández, José and Vergara Pavón, María José and Guerrero, M. and Fernández, O. and Piédrola Angulo, Gonzalo and Morales, Patricia and Maroto Vela, María del Carmen},
}