@misc{10481/89956,
year = {2002},
month = {3},
url = {https://hdl.handle.net/10481/89956},
abstract = {Objectives: Epstein-Barr virus (EBV) is frequently associated with malignant cell transformation through the action of the oncoprotein latent membrane protein-1 (LMP-1). The present study aimed to determine the presence of EBV in oral squamous cell carcinomas (OSCCs) and the expression of LMP-1 in neoplastic cells of EBV-positive OSCCs.

Study design/methods: In a retrospective study of 78 OSCCs, we investigated the presence of the DNA of EBV by polymerase chain reaction, the expression of the oncoprotein LMP-1 by immunohistochemistry, and the presence of EBV-encoded RNA (EBER) by in situ hybridization.

Results: EBV DNA was detected in 19.2% of the cases. Expression of LMP-1 in neoplastic cells was found in 85.7% of the EBV-positive OSCCs. EBV presence was significantly more frequent (P <.05) in OSCCs localized on the lateral tongue. EBV-positive OSCCs more frequently presented (P <.05) greater nuclear atypia.

Conclusion: EBV can appear in latent form in OSCC and express its main oncoprotein, LMP-1.},
publisher = {Wiley},
keywords = {Epstein-Barr virus},
keywords = {Latent membrane protein-1},
keywords = {Oral squa-mous cell carcinoma},
title = {Epstein-Barr virus latent membrane protein-1 (LMP-1) expression in oral squamous cell carcinoma},
doi = {10.1097/00005537-200203000-00014},
author = {González Moles, Miguel Ángel and Gutiérrez Fernández, José and Rodríguez, M. J. and Ruiz-Avila, I. and Rodríguez-Archilla, Alberto},
}