@misc{10481/88882,
year = {2021},
url = {https://hdl.handle.net/10481/88882},
abstract = {Training induces a number of healthy effects including a rise in skeletal muscle (SKM)
glucose uptake. These adaptations are at least in part due to the reactive oxygen
species produced within SKM, which is in agreement with the notion that antioxidant
supplementation blunts some training‐induced adaptations. Here, we tested whether
hydroxytyrosol (HT), the main polyphenol of olive oil, would modify the molecular
regulators of glucose uptake when HT is supplemented during exercise. Rats were
included into sedentary and exercised (EXE) groups. EXE group was further divided
into a group consuming a low HT dose (0.31 mg·kg·d; EXElow), a moderate HT dose
(4.61mg·kg·d; EXEmid), and a control group (EXE). EXE raised glucose transporter
type 4 (GLUT4) protein content, Ras‐related C3 botulinum toxin substrate 1 (Rac1)
activity, and protein kinase b (AKT) phosphorylation in SKM. Furthermore, EXElow
blunted GLUT4 protein content and AKT phosphorylation while EXEmid showed a
downregulation of the GLUT4/AKT/Rac1 axis. Hence, a low‐to‐moderate dose of HT,
when it is supplemented as an isolated compound, might alter the beneficial effect of
training on basal AKT phosphorylation and Rac1 activity in rats.},
title = {Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats},
doi = {10.1002/jcp.29876},
author = {Rodríguez Huertas, Jesús Francisco},
}