@misc{10481/88820,
year = {2018},
month = {2},
url = {https://hdl.handle.net/10481/88820},
abstract = {Background & aims: In recent years, obesity has reached alarming levels among children and adolescents. The study of plasma fatty acid (FA) composition, as a reflection of diet, and its associations with other parameters, that are closely linked to obesity and the cardiometabolic profile, may be useful for setting nutritional goals for obesity treatment and prevention. This study explored the role of plasma FA levels as modulators of body fat and cardiometabolic risk markers, in overweight adolescents.
Methods: A multidisciplinary weight loss program was followed by 127 overweight and obese adolescents aged 12-17 years old. Plasma FA composition, anthropometric indicators of adiposity and biochemical parameters were analyzed at baseline, two months (the end of the intensive intervention phase) and six months (the end of the extensive phase).
Results: While saturated fatty acid (SFA) and n-6 polyunsaturated fatty acid (PUFA) levels  decreased significantly during the intervention, monounsaturated fatty acid (MUFA) and n-3 PUFA showed the opposite trend. The decrease in SFA C14:0 was associated with a reduction in total and LDL cholesterol, apolipoprotein B and insulin. The increase in MUFAs, especially C18:1n-9, was related to a reduction in weight, fat mass, fat mass index and glucose. Regarding PUFAs, changes in the n-3 series were not associated with any of the parameters studied, whereas the reduction in n-6 PUFAs was directly related to weight, fat mass, total and HDL cholesterol, apolipoprotein A1, glucose and insulin, and inversely associated with diastolic blood pressure. The adolescents with greater weight loss presented significant changes in MUFAs, n-6 PUFAs and C14:0.
Conclusions: Modifications in plasma FA composition could help modulate adiposity and the cardiometabolic profile in anti-obesity programs aimed at adolescents. The changes observed in FA composition were related to the success of the treatment, since the individuals most affected by these variations were those who presented the greatest weight loss.},
organization = {This work is part of the EVASYON study funded by the Spanish 326 Ministry of Health and Consumption (Carlos III Institute of Health. FIS. Grant PI 051579). The EVASYON study has received the award from AESAN (Spanish Agency for Food Security and Nutrition) from the Spanish Ministry of Health and Consumption to the best applied research project in 2009.},
publisher = {Churchill Livingstone in Clinical Nutrition},
keywords = {Adiposity},
keywords = {cardiometabolic profile},
keywords = {obese adolescents},
keywords = {plasma fatty acids},
keywords = {weight loss},
title = {Changes in plasma fatty acid composition are associated with improvements in obesity and related metabolic disorders: A therapeutic approach to overweight adolescents},
doi = {doi: 10.1016/j.clnu.2016.11.006.},
author = {Guerendiain, Marcela and Montes, Rosa and López-Belmonte, Gema and Martín-Matillas, Miguel and Castellote, Ana and Martín-Bautista, Elena and Martí, Amelia and Martínez, Alfredo and Moreno, Luis and Garagorri, Jesús Mª and Wärnberg, Julia and Caballero, Javier and Marcos, Ascensión and López-Sabater, M Carmen and Campoy Folgoso, Cristina},
}