@misc{10481/88616,
year = {2020},
month = {2},
url = {https://hdl.handle.net/10481/88616},
abstract = {Circulating microRNAs serve as stable and cross-species biomarkers. MicroRNA-122 (miR-122) is a reliable hepatocyte-specific biomarker for drug-induced liver injury (DILI). We developed a dynamic chemical labeling (DCL) assay enabling direct detection of miR-122 in blood, with high specificity and sensitivity from small sample volumes. This assay accurately identifies DILI in humans and animals, offering improved stability and isomiR detection compared to PCR methods.},
organization = {J.D.T. was supported by a Ph.D. studentship from TheCunningham Trust. J.W.D. was supported by an NHSResearch Scotland (NRS) Career Research Fellowship throughNHS Lothian and acknowledges the contribution of the BritishHeart Foundation Centre of Research Excellence Award (RE/08/001). This research was partially supported by the Ministryof Economy and Competitiveness, Spain (BIO2016-80519-R)and Health Insitute Carlos III (ISCIII) (Projects oftechnological development in health - ref DTS18/00121).},
publisher = {ACS Publications},
title = {Direct Detection of miR-122 in Hepatotoxicity Using Dynamic Chemical Labeling Overcomes Stability and isomiR Challenges},
doi = {10.1021/acs.analchem.9b05449},
author = {López-Longarela, B and Morrison, EE and Tranter, JD and Chahman-Vos, L and Léonard, JF and Gautier, JC and Laurent, S and Lartigau, A and Boitier, E and Sautier, L and Carmona-Saez, P and Martorell-Marugan, J and Mellanby, RJ and Pernagallo, S and Ilyine, H and Rissin, DM and Duffy, DC and Dear, JW and Diaz Mochon, Juan José},
}