@misc{10481/88577,
year = {2019},
url = {https://hdl.handle.net/10481/88577},
abstract = {Retrotransposons are a type of transposable element
(TE) that have amplified to astonishing numbers in
mammalian genomes, comprising more than a third
of the human and mouse genomes. Long interspersed
element class 1 (LINE-1 or L1) retrotransposons
are abundant and currently active retroelements
in the human and mouse genomes. Similarly, long
terminal repeat (LTR)-containing retrotransposons
are abundant in both genomes, although only active
in mice. LTR- and LINE-1-retroelements use different
mechanisms for retrotransposition, although both
involve the reverse transcription of an intermediate
retroelement-derived RNA. Retrotransposon activity
continues to effect the germline and somatic genomes,
generating interindividual variability over
evolution and potentially influencing cancer and brain
physiology, respectively. However, relatively little is
known about the functional consequences of retrotransposition.
In this study, we have synthesized
and characterized reverse transcriptase inhibitors
specific for mammalian LINE-1 retrotransposons,
which might help deciphering the functional impact
of retrotransposition in vivo.},
organization = {G.B.-S. is funded by a ‘‘Garantı´a Juvenil’’ contract from
the European Social Fund in collaboration with the Andalusian Regional Government.
M.B.-G. is funded by a ‘‘Formacion Profesorado Universitario’’ (FPU)
PhD fellowship from the Government of Spain (MINECO, Ref FPU15/03294). In
J.L.G.-Perez’s lab, this study has been funded by an International Early Career
Scientist grant from the Howard Hughes Medical Institute (IECS-55007420)
and by a private donation from Ms Francisca Serrano (Trading y Bolsa para
Torpes, Granada, Spain). J.L.G.Perez’s lab is also supported by the European
Research Council (ERC-Consolidator ERC-STG-2012-309433), and by
MINECO-FEDER (SAF2017-89745-R).},
publisher = {Elsevier},
title = {Synthesis and Characterization of Specific Reverse Transcriptase Inhibitors for Mammalian LINE-1 Retrotransposons},
doi = {10.1016/j.chembiol.2019.04.010},
author = {Bañuelos Sánchez, Guillermo and Rodríguez Heras, Sara and Franco Montalbán, Francisco and Tamayo Torres, Juan Antonio and García Pérez, José Luis},
}