@misc{10481/88145,
year = {2017},
month = {9},
url = {https://hdl.handle.net/10481/88145},
abstract = {Mesoporous silica Al-MCM-41 nanoparticles have been used, for the first time, as vehicles for the single and dual encapsulation of the cationic CO-releasing molecule (CORM) [Mn(1,4,7-triazacyclononane)(CO)3]+ (ALF472+) and the well-known antineoplastic drug, cis-[PtCl2(NH3)2] (cisplatin). Thus, two new hybrid materials, namely, ALF472@Al-MCM-41 and ALF472-cisplatin@Al-MCM-41, have been isolated and fully characterized. The results reveal that the presence of CORM molecules enhances cisplatin loading 3-fold, yielding a cargo of 0.45 mmol g–1 of ALF472+ and 0.12 mmol g–1 of the platinum complex for ALF472-cisplatin@Al-MCM-41. It is worth noting that ALF472@Al-MCM-41 shows a good dispersion in phosphate buffered saline solution, while the dual hybrid material slightly aggregates in this simulated physiological medium (hydrodynamic size: 112 ± 23 and 336 ± 50 nm, respectively). In addition, both hybrid materials (ALF472@Al-MCM-41 and ALF472-cisplatin@Al-MCM-41) behave as photoactive CO-releasing materials, delivering 0.25 and 0.11 equiv of CO, respectively, after 24 h and exhibiting a more controlled CO delivery than that of the free CORM. Finally, metal leaching studies have confirmed the good retention capacity of Al-MCM-41 toward the potentially toxic manganese fragments (86% of retention after 72 h) as well as the low release of cisplatin (ca. 7% after 72 h).},
organization = {The Spanish Ministry of Economy and Competitivity and UE Feder Program (Projects CTQ2014-53486R and CRM Juan de la Cierva Contract), University of Granada (CRM Reincorporación Plan Propio), Junta de Andalucía (Project P09-FQM-4981 and S.R. postdoctoral contract), and COST action CM1105 are gratefully acknowledged for generous funding. The authors thank Alfama Inc. for providing ALF472. We thank Helia Jeremias and Helena Laronha for the synthesis and purification of ALF472 batches. The NMR data were acquired at CERMAX (Centro de Ressonância Magnética António Xavier), which is a member of the National NMR network.},
publisher = {ACS},
title = {Aluminum Doped MCM-41 Nanoparticles as Platforms for the Dual Encapsulation of a CO-Releasing Molecule and Cisplatin},
doi = {https://doi.org/10.1021/acs.inorgchem.7b01475},
author = {Carmona Fernández, Francisco Jesús and Jiménez-Amezcua, Ignacio and Rojas Macías, Sara and Romão, Carlos C. and Rodríguez Navarro, Jorge Andrés and Rodríguez Maldonado, Carmen and Barea Martínez, Elisa María},
}