@misc{10481/88086,
year = {2017},
month = {1},
url = {https://hdl.handle.net/10481/88086},
abstract = {Two novel anthracene-based half-sandwich organometallic Ru(II) compounds, namely, [Ru(p-cymene)(L1)Cl2] (1) and [Ru(p-cymene)(L2)Cl2] (2) (L1 = 1-(anthracen-9-yl)-N-(pyridin-3-ylmethyl)methanamine; L2 = 1-(anthracen-9-yl)-N-(pyridin-4-ylmethyl)methanamine) have been synthesized and characterized. We demonstrate that the fluorescence properties of these complexes are highly affected by the linking position of the anthracene unit, as only 2 shows fluorescence emission in the blue region. Regarding their biological activity, both ruthenium metallodrugs show interaction with different biological targets such as S-donor amino acids (cysteine) and proteases (cysteine cathepsin B). Moreover, 1 and 2 show in vitro cytotoxicity against HL-60 cancer cell line (IC50 = 84.5 and 87.0 μM for 1 and 2, respectively), with cell death occurring via apoptosis. Further studies have shown that diffusion into cells is the main mechanism of metallodrug uptake. Finally, as a proof of concept, these ruthenium complexes have been successfully encapsulated into MCM-41 and SBA-15 mesoporous silicas using two different incorporation strategies (impregnation and grinding).},
organization = {The Spanish Ministry of Economy and Competitiveness and UE Feder Program (projects CTQ2014-53486R and CRM Juan de la Cierva Contract), Junta de Andalucía (project P09-FQM-4981 and SR postdoctoral contract), CEI BioTic Granada (project CEI2015-MP-BS39) and COST action CM1105 are gratefully acknowledged for generous funding.},
publisher = {Elsevier},
title = {Inorganic mesoporous silicas as vehicles of two novel anthracene-based ruthenium metalloarenes},
doi = {10.1016/j.jinorgbio.2016.11.004},
author = {Rojas Macías, Sara and Carmona Fernández, Francisco Jesús and Barea Martínez, Elisa María and Rodríguez Maldonado, Carmen},
}