@misc{10481/87876,
year = {2020},
month = {8},
url = {https://hdl.handle.net/10481/87876},
abstract = {Background: Ethanol use during adolescence is a significant health problem, yet the pharmacological treatments to reduce adolescent binge drinking are scarce. The present study assessed, in male and female adolescent Wistar rats, if the sigma-1 receptor (S1-R) antagonists S1RA or BD-1063 disrupted ethanol drinking.

Methods: Three times a week, for two weeks, the rats received the S1-R antagonists. Thirty min later they were exposed, for 2 h, to a bottle of 8% or 10 % v/v ethanol. A 24 h, two-bottle, ethanol intake test was conducted after termination of these procedures. A subset of these rats was tested for recognition memory via the novel object recognition test.

Results: The rats given 64 mg/kg S1RA drank, in each binge session, significantly less than vehicle counterparts. Male rats given 4 or 16 mg/kg S1RA drank significantly less than those given 0 mg/kg in session 3 or in session 1 and 2, respectively; whereas female rats given 4 or 16 mg/kg drank significantly less than females given 0 mg/kg in session 2-5 or in sessions 2-6, respectively. Administration of 32 mg/kg, but not of 2 or 8 mg/kg, BD-1063 suppressed, across sessions, ethanol drinking. S1-R antagonism reduced absolute ethanol drinking at the two-bottle choice post-test. Recognition memory was not affected by the ethanol exposure.

Conclusions: The results indicate that S1-R antagonists may be promising targets to prevent increases in ethanol intake at adolescence. The persistent effect of S1-R antagonism in free-choice drinking suggests that modulation of the S1-R is altering plastic effects associated with ethanol exposure.},
organization = {This work was supported by PICT 2015-0325 of Agencia Nacional de Promoción Científica y Tecnológica (FONCyT), to RMP; by the Junta de Andalucía (grant CTS 109), and by funding from Esteve Pharmaceuticals and the European Regional Development Fund (ERDF). This research was done in partial fulfillment of the requirements for the doctoral thesis of LR-L, who was supported by a predoctoral grant from the Programa de Movilidad Internacional para Estudiantes de Doctorado 2019/20 of the University of Granada. The funders had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.},
publisher = {Elsevier},
keywords = {Ethanol},
keywords = {sigma-1 receptors},
keywords = {Rats},
keywords = {Adolescence},
keywords = {Binge Drinking},
keywords = {Sex differences},
title = {Sigma-1 antagonism inhibits binge ethanol drinking at adolescence},
doi = {10.1016/j.drugalcdep.2020.108214},
author = {Cendán Martínez, Cruz Miguel and Ruiz Leyva, Leandro and Morón Henche, Ignacio},
}