@misc{10481/87331,
year = {2015},
url = {https://hdl.handle.net/10481/87331},
abstract = {Aberrant fibrogenesis is a feature of many diseases in multiple organ systems. The lysyl oxidase family of
enzymes are central to tissue homeostasis and elevated lysyl oxidase activity is implicated in
fibroproliferation as well as in cancer stroma. We have synthesised a novel fluorogenic reporter for
monitoring lysyl oxidase activity that generates a 3–5 fold increase in fluorescence following probe
activation in ventilating fibrotic ex vivo asinine lung and ex vivo human lung tissue. The probe termed
“oLOX” can provide real-time measurement of lysyl oxidase activity in a number of biological settings
and is tractable from an in vitro setting to man},
organization = {The authors would like to thank the MRC, under the Developmental Pathway Funding Scheme (grant number RA2159).
A.M-F. acknowledges Fundacion Ramon Areces-Postdoctoral
Research Fellowship Program for Financial support. The
research leading to these results has received funding from the
European Union Seventh Framework and EPSRC (EP/
K03197X).},
publisher = {Royal Society of Chemistry},
keywords = {LOX},
keywords = {Optical imaging},
keywords = {Fluorescence},
title = {Optical molecular imaging of lysyl oxidase activity– detection of active fibrogenesis in human lung tissue},
doi = {10.1039/c5sc01258a},
author = {Aslam, Tashfeen and Miele, Amy and Chankeshwara, Sunay V. and Megía Fernández, Alicia and Michels, Chesney and Akram, Ahsan R. and McDonald, Neil and Hirani, Nik and Haslett, Chris and Bradley, Mark and Dhaliwal, Kevin},
}