@misc{10481/87313,
year = {2021},
month = {1},
url = {https://hdl.handle.net/10481/87313},
abstract = {One of the major applications of SerumAlbumins is their use as delivery systems for lipophilic compounds in biomedicine.
Their biomedical application is based on the similarity with Human Serum Albumin (HSA), as a fully
biocompatible protein. In general, Bovine Serum Albumin (BSA) is treated as comparable to its human homologue
and used as a model protein for fundamental studies since it is available in high amounts and well understood.
This protein can act as a carrier for lipophilic compounds or as protective shell in an emulsion-based
vehicle. Polysaccharides are generally included in these formulations in order to increase the stability and/or applicability
of the carrier. In this review, themain biomedical applications of Albumins as drug delivery systems are
first presented. Secondly, the differences between BSA andHSA are highlighted, exploring the similarities and differences
between these proteins and their interaction with polysaccharides, both in solution and adsorbed at interfaces.
Finally, the use of Albumins as emulsifiers for emulsion-based delivery systems, concretely as Liquid
Lipid Nanocapsules (LLNs), is revised and discussed in terms of the differences encountered in the molecular
structure and in the interfacial properties. The specific case of Hyaluronic Acid is considered as a promising additivewith
important applications in biomedicine. The literatureworks are thoroughly discussed highlighting similarities
and differences between BSA and HSA and their interaction with polysaccharides encountered at
different structural levels, hence providing routes to control the optimal design of delivery systems.},
organization = {This work has been funded by the following projects, which are
gratefully acknowledged: MAT2017-82182-R and RTI2018-101309-BC21
(Ministerio de Ciencia e Innovación). The authors also acknowledge
“Mancomunidad de los Pueblos de la Alpujarra Granadina” for the funds
raised and supplied for this research.},
publisher = {Elsevier B.V.},
title = {Applications of serum albumins in delivery systems: Differences in interfacial behaviour and interacting abilities with polysaccharides},
doi = {https://doi.org/10.1016/j.cis.2021.102365},
author = {Aguilera-Garrido, Aixa and Castillo Santaella, Teresa del and Yang, Yan and Galisteo-González, Francisco and Gálvez-Ruiz, María José and Molina Bolívar, José Antonio and Holgado-Terriza, Juan Antonio and Cabrerizo-Vílchez, Miguel Ángel and Maldonado-Valderrama, Julia},
}